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《China Preventive Medicine》 2000-01
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Maternal, Prenatal and Perinatal Risk Factor for Cerebral Palsy: a Case - control Study in Rural Areas in Anhui Province

TAO Fang - biao, NIN Jin-fa, ZHANG Hong - bo, et al. Departement of Epidemiology, Shanghai Medical University, Shanghai 200032, China.  
Objective To investigate the relationship between a series of matemal, antenatal, and perinatal variables and the occurrence of cerebral palsy (CP) and discuss the interactions of the risk factors at different stages of prenancy. Methods Population based case - control design was carried out. 97 children with CP aged 1 to 8 years from the rural areas in Anhui Province were studied using 285 healty children from the same villages or towns as control. Statistical analysis was done by modeling the data through unconditional Logistic regression.Results Statistically significant (P0.05) risk factors were maternal age over 30 years old (OR = 2.99, 95%CI 1.24-7.25), maternal history of spontaneous abortion (OR = 3.66, 95%CI 1.74 - 7.70), more than 24 hours of delivery course (OR=6.27, 95%CI 2.61 - 15.09), delivery at home (OR = 1.89, 95% CI 1.13 - 3.18), and more than 14 days of neonatal jaundice (OR = 4.52, 95%CI 2.00 - 10.22) .The relationship between history of matemal abortion and more than 40 days of menstrual cycle was found. Delayed crying of the neonatal baby was correlated with long time to delivery. Conclusions Certain maternal variables may increase the vulnerabilities of fetal brain development. Perinatal asphyxia and lasting neonatal jaundice are still the causes of CP in rural areas.
【Fund】: 安徽省卫生厅自然科学基金(A95-1998-07)
【CateGory Index】: R742.3
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