Relationship between Virus Contents in Sera of Children and Vertical Transmission of HB
FU Hai - jun, LI Rong - cheng, MA Jing - chen , et al. Department of Epidemiology, School of Public Health , Shanghai Medical University, Shanghai 200032. China
Objective To investigate the relationship of the virus content in the sera of children HBsAg chronic carrier and vertical transmission.Methods 214 HBsAg chronic carrier children identified by population- based sampling were investigated and all the subjects and their mothers were bleed; HBV sero- markers and HBsAg liters were detected with ELISA kits.Results In comparison witll those whose mothers were HBsAg negative carrier cluldren with HBsAg positive mothers had higher HBsAg liters and HBeAg positive rate, but lower annual sero - conversion rate of HBsAg (0.4% vs 1.7%), and their mothers' annual sero - conversion rate of HBsAg was 0.3% . Conclusions High HBV level may play a major role in maternal - infant transmission and high HBsAg positive rate in China.
【CateGory Index】： R725.1