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Applied Study on Biomonitoring Indexes for Fluoroacetamide Poisoning

ZHENG Qiao - ling, LI Lai - yu, HUANG Jian -xun, et al. Guangdong Prevention and Treatemt Center for Occupational Diseases, Guangzhou 510300, China  
Objective To study the application of two possible biomonitoring indexes, blood citrate and urine floride, for diagnosing fluoroacetamide poisoning.Methods Blood citrate and urine floride were dynamically analysed by enzyme and oxygen flask/ fluoride selective electrode methods respectively, in rats and in human. Results Both tested indexes increased obviously in animals and in human in the initial stages of poisoning, and they dropped gradually along with the course of poisoning. A dose - effect relationship was observed in the animal. Convulsion and death of the animals related to the contents of citrate. Floride could be decomposed and excreted quite fast in rats.Conclusions It is demonstrated that the two indexes are sensitive and specific, and that the combinative application of this two tests are valuable in diagnosing fussol poisoning. This paper also provides some data on mechanism of fluoroacetamide poisoning.
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