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《China Preventive Medicine》 2000-01
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The Relationship between Serum Sex Hormone Levels and Rheumatoid Arthritis,

SHEN Chang, ZHAI Jin - xia, YE Dong -qing. Department of Epidemiology, College of Public Health , Anhui Medical University, Hefei 230032 , China  
Objective To investgate the effect of serum estradiol (E2), testosteron (T), prolactin (PRL), follicle stimulating hormone (FSH), luteinnizing hormone (LH), progesterone (P) on rheumatoid arthritis.Methods Radioimmunological technology was carried to assay the serum sex hormone and SPSS software was used to process the data. Results (1) The E2, P levels of RA group were apparently lower than that of control group ( P 0.05) and the PRL and FSH of RA were evidently lugher than control (P0.05) . (2) Serum E2 of RA showed significantly lower than control in male (P0.05); and LH, conversely, was lugher than control ( P 0.05); There were no significant difference of serum T and P between men and women in RA group ( P 0.05) . (3) In the first menstrual age earlier than 14 - year - old group, RA patients' serum P showed significantly lower than that of individuals (P0.05); As for older than 14- year- old group , serum LH of RA patients level was higher than riatral individuals ( P 0.05) . (4) Serum P in RA was apparently lower than control among gravid times more than 3 times ( P 0.05); As for the first gravidity age from 20 to 24 years old group ( P 0.05), serum PRL and LH of RA increase apparently than control. (5) Serum T of RA showed statistically higher than control among women who never abored; Serum P level of RA was significantly lower than normal individuals (P0.05) .Conclusions We assayed the six serum sex hormone, the results presented partly difference in sex, first menstrual age, fisrt gravidity age, gravidity times, ever aborted of not, between RA and control which suggested the important role of sex honnone should be taken into account in the etiology of RA.
【Fund】: 安徽省自然科学基金(98437231);; 安徽省高等学校自然科学基金(98JL080)
【CateGory Index】: R593.22
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