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HIV Prevalence and Subtypes among Paid Blood Donors in Shandong and Hubei Provinces, China

LIU Shu - zhen , ZHENG Xi - wen, FU Ji - hua, et al. Sanitary and Anti - epidemic Station of Shandong Province, Jinan 250014, China  
Objective To determine the prevalence and distribution of HIV infection and subtypes among paid blood donors.Methods A cluster sanipling method was used to survey 645 paid blood donsrs from villages in Shandong and Hubei provinces.Blood samples were collected and screened using ELISA and confirmed with WB for detecting HIV antibodies.DNA gene se-quencing was conducted to identify HIV subtypes and strains.ResultS HIV prevalence among blood donors was 3.26%(21/645) .Xi-angfan in Hubei province had a prevalence rate of 9.05% ,much higher than Xintai in Shandong province with 0.46% .Prevalence rates were higlier among plasma donors(7.80%)compared to blood donors only(1. 14%) .HIV sequence analysis showed that HIV infected strains in blood donors was a HTV - 1 subtype B' (Thailand B)strain.The genen'c divergence inner - group was 4.53% of the two strains found in Xintai,and 2.92% of the four strains from Xiangfan. Conclusion There were significant differences in HIV prevalence among blood donors from different areas in China.The history of plasma donation is a risk factor for HIV infection.The strain found among HIV infected blood donors was a HIV -1 subtype B'(Thailand B)strain.It was estimated that HIV has been transmitted from one blood donor to another for approximately 3-6 years.
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