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Nested Case - Control Study on the Relationship of Hp Infection and Gastric Cancer Risk

WANG Tao , CHEN Kun, WANG Run - tian, ea al. Peking University Health Science Center, Beijing 100083, China  
Objective The aim of tliis study was to explore the relationship of Helicobacter pylori (Hp) infection and gastric cancer risk.Methods Follow- up was conducted ainong those who had participated in 1980- 1988 gastric cancer census in Muping, Shandong Province and Daishan, Zhejiang Province.Hp infection was examined by Wartliin - Starring stain to the biopsy specimen stored. A nested case - control study was conducted, for each patient died of gastric cancer four controls was matched on residence, age and sex.ResultS After adjustment and control of confounding factors, the results of multiple variants conditional Logistic analysis showed tliat Hp infection (OR = 4.4467, 95% CI 1. 161 - 17.19) is a risk factor of gastric cancer.Smoking is also one of the risk factors of gastric cancer. Conclusions The result showed that Hp infection was one of risk factors of gastric cancer.
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