The Toxicity and Allergy Effect of d - Trans - Allethrin
TANG Xiao - jiang, CHEN Run - tao, DENG Yaig - yu, et al. Guangdong Prevention and Treatment Center for Occupational Diseases, Guangzhou, 510300, China
Objective To understand the toxicity and allergy of d - trans - allethrin.Methods SD rats were used in oral, dermal and inllalation acute toxicity tests, and also in 90 - day subchronic oral toxicity test. NIH mice were used in subcutaneous and in-traperitoneal acute toxicity tests. New Zealand white rabbits were used in primary eye and skin irritation tests. Guinea pigs were used in skin sensitization test. Ames test was done as well.Results The Lethal Dose 50 (LD50) of rats by oral test was 619mg/kg in female (F) and 1 100mg/kg in male (M), rats dermal test was showed 4 200mg/kg (F) and 2 710mg/kg (M) .Mice intraperitoneal test showed LD50 was 584mg/kg (F) and 681mg/kg (M) while mice subcutaneous test was 4 300mg/kg (F) and 3 690mg/kg (M) . Lethal Concentration 50 (LC50) of rats was 2 550mg/m3 (F/M ) . The irritating potency both in eye and skin tests were estimated as week irritation. Allergic reactions were observed in Guinea pigs (14.3%). The NOAEL of 90- day oral tests is 13.097mg·kg-1·d-1. The result of Ames test was negative. Condusions d - trans - allethrin is of low toxicity and it is a mild allergy substance.