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Meta-analysis on the positive rate of hepatitis B surface antigen among pregnant women in China

SHI Guo,ZHANG Shun-xiang School of Public Health,Zhengzhou University,Henan,Zhengzhou 450001,China  
Objective To systematically evaluate the national positive rate of hepatitis B surface antigen(HBsAg) among pregnant women in China by meta-analysis.Methods Publications regarding the positive rate of HBsAg among pregnant women between 2002 and 2012 were extracted from China National Knowledge Infrastructure(CNKI),Chinese science technology journal database(VIP),Wanfang database and PubMed,The Meta positive rate was estimated using generic inverse variance model and the random effect model provided by MetaAnalyst software.Results Thirty-five papers were retrieved with a total sample size of 224 029.The weighted positive rate was 7.91%(95% CI:7.78%-8.03%) estimated by generic inverse variance model and 7.60%(95% CI:6.50%-8.70%)by the random effect model provided by MetaAnalyst software.Because of the heterogeneity of included studies,the result acquired by MetaAnalyst software was more accurate.Conclusions The result of the meta-analysis is almost consistent with the result of national epidemiological survey,indicating that Meta analysis is reliable,which provides key parameter for making strategies to prevent maternal-infantile transmission.
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