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Meta-analysis on major risk factors of Alzheimer′s disease in China

LONG Yuan-xian,TANG Yu-meng,TANG Li-jun Maternal and Child Health Hospital of Huangzhou District,Huanggang,Hubei 438000,China  
Objective To assess the major risk factors of Alzheimer′s disease by Meta analysis and to provide evidence for the prevention and diagnosis of Alzheimer′s disease.Methods Data of recently published case-control studies on Alzheimer′s disease were collected by literature search in Chinese database and analyzed by Meta-analysis software RevMan.Results The OR values for hypertension and family history of transmissible dementia were 1.37(95% CI: 0.96-1.95)and 2.35(95% CI: 1.45-3.85)respectively.Meanwhile,the OR values for smoking,high-education and social activity were 0.85(95% CI: 0.52-1.39),0.55(95% CI: 0.45-0.67) and 0.48(95% CI:0.25-0.92)respectively.Conclusions Hypertension and family history of transmissible dementia are the major risk factors for Alzheimer′s disease,while high-education and social activity are the protective ones.
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