Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Medical Journal of Metallurgical Industry》 2010-01
Add to Favorite Get Latest Update

The effect of Tetramethylpyrazine on telomerase activity and apoptosis in leukemia K562 cells

WU Tao,QU Gui-fang.Department of Hematology,The General Hospital of WISCO,Wuhan,430080  
Objective:To investigate the effects of Tetramethylpyrazine(TMP)on telomerase activity and apoptosis in K562 cells lines and study the melocular mechanism of it's antileukemic.Methods:Cell apoptosis was observed by light microscopy and transmission electron microscopy.The expression of Fas was measured by flow cytometry.Polymerase chain reaction enzyme linked immunoassay(PCR-ELISA)was used to assay telomerase activity of K562 cells.Results:Tetramethylpyrazine could inhibit telomerase activity of K562 cells in a time-and-concentration-dependentmanner.Meanwhile,it could induce apoptosis obviously and up-regulate the levels of Fas in K562 cells.Conclusions:Tetramethylpyrazine could inhibit telomerase activity of K562 cells,and the mechanism of effect was maybe relate to inducing apoptosis and the expression of Fas protein.
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 2 Hits
1 LI Nai nong,CHEN Yuan zhong,LU Lian huang. Fujian Institute of Hematology, Union Hospital of Fujian Medical University (Fuzhou,350001);STUDY ON THE EXPRESSION OF TELOMERASE ACTIVITY IN LEUKEMIA CELLS[J];Journal of Leukemia;2002-05
2 XIAO Yang, ZHANG Huan Institute of Hematology, Ji'nan University Medical College, Guangzhou 510632, China;Effect of antisense oligodeoxynucleotides of RNA component of human telomerase on cisplatin induced apoptosis in K562cells[J];Journal of First Military Medical University;2003-02
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 YU Bingxiang*, ZHU Jie, LIU Youning, ZHENG Xiaofei. *Department of Respiratory Medicine, Chinese PLA General Hospital, Beijing 100853, P.R.China;An experimental study of telomerase reverse transcriptase (hTERT) DNAzyme on growth of A549/DDP cells[J];Chinese Journal of Lung Cancer;2006-05
2 Xiao Yang,Zhang Huan,He Dongmei. Hematology Department of Guangzhou General Command Hospital, Guangzhou 510010;The effect of human telomerase RNA(hTR) antisense oligodeoxynucleotides on telomerase acitvity and apoptosis in primary acute leukemia cells[J];Guangdong Medical Journal;2004-12
3 GAO Hong-quan~(1*) SUN Ping~2 WANG Ying~1 1.Xiamen Medical College,Fujian Xiamen 361008; 2.Department of Anatomy of Mudanjiang Medical College,Heilongjiang Mudanjiang 157011 China;The Expressions of VEGF-C, VEGFR-3 and iNOS in Lgmphatic Vessels of Human Breast Cancer[J];Progress of Anatomical Sciences;2008-02
4 LI Xiao-ming,HAN Jian-qun.Department of Medical,Affiliated Hospixal of Luzhou medical college,Luzhou 646000,China.;Expression of VEGF and MDR1 in acute myeloid leukemia patients and the relation with prognosis[J];Journal of Modern Oncology;2006-02
5 LAI Jian-Ping1,HUANG Jie21The Second Department of Internal Medicine,Jiangshan People Hospital,Quzhou 324100,Zhejiang Province,China;2Department of Hematology,The First Hospital of Fujian Medical University,Fuzhou 350004,Fujian Province,China;Suppressive Effect of Artesunate on K562 Cell Growth and Its Influence on VEGF Expression[J];Journal of Experimental Hematology;2008-04
6 YUAN Yu_ning,ZHANG Xing_xing,ZHU Yi_wen (Department of Hematology, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001,China);Detection and clinical significance of vascular endothelial growth factor in acute leukemia patients[J];Journal of Postgraduates of Medicine;2004-11
7 QIAN Jie-jing,JIN Jie(The Hematology Department of The First Hospital,Zhejiang University School of Medicine,Hematology Institution of Zhejiang University,Hangzhou 310003,China);Interferon-α in combination with homoharringtonine induces K562 cell apoptosis through down-regulating human telomerase reverse transcriptase expression and telomerase activity[J];Chinese Journal of Pathophysiology;2006-09
8 CHENG Peng1,PENG Zhi-gang1,YANG Jie1,SONG Shan-jun2(1.Department of Hemotology,The First Affiliated Hospital,Guangxi Medical University,Nanning 530021,China;2.Department of Hemotology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China);The Effect of Mangiferin on Telomerase Activity and Apoptosis in Leukemic K562 Cells[J];Journal of Chinese Medicinal Materials;2007-03
9 Peng Zhiang1, Luo Jun1,Lai Yongrong2,Song Shanjun2(1Department of Hemotology,The First Affiliated Hospital,Guangxi Medical University,Nanning 530021;2Department of Hemotology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 4300222);Effect of Mangiferin on telomerase activity and cell cycle in K562 cells[J];Pharmacology and Clinics of Chinese Materia Medica;2007-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Liu Ying1,Gao Chao2,Cai Xiaomin3,Hao Xingzhi2(1.Department of Obstetrics and Gynecology,the Affiliated Hospital of Xuzhou Medical College,Xuzhou 221006,China;2.Department of Oncology,the Affiliated Hospital of Xuzhou Medical College,Xuzhou 221006,China;3.Department of Oncology,Xinhua Hospital of Yili Autonomous City,Yili 835000,China);Effect of Hedyotic Diffusa on Telomerase Activity and hTERT Gene Expression in Human Cervical Carcinoma Hela Cells[J];Journal of Basic and Clinical Oncology;2010-02
2 TANG Fa qing, TIAN Dao fa, CHEN Zhao hui (Central Research Laboratory, Xiangya Hospital, Central South University, Changsha 410078, China);Inhibitory effect of YIQIJIEDU powder to telomerase and telomerase RNA in nasopharyngeal tumorigenesis of rats[J];Bulletin of Hunan Medical University;2001-04
3 LOU Jia-ning,ZHOU Zeng-tong. Department of Stomatology,Shanghai First People's Hospital,Shanghai Jiaotong University,Shanghai 200080,China.;The study of Yun Zhi Polysaccharopeptide chemoprevention on altered telomerase activity during golden hamster cheek pouch carcinogenesis[J];Journal of Clinical Stomatology;2008-06
4 LOU Fang, QIN Shu-kui, CHEN Hui-ying. The PLA Cancer Center of the 81 st Hospital, Nanjing 210002, China;Influence of telomerase activity of human hepatocellular carcinoma cell lines by aresenic trioxide[J];Chinese Clinical Oncology;2006-04
5 Lei Shuisheng,Zhu Xiaoqin,Zhang Duanlian Xian Ning Medical College;EFFECTS OF LIGUSTRAZINE ON TELOMERASE ASSOCIATED WITH SKIN INJURY IN PSORIASIS[J];Qinghai Medical Journal;2003-08
6 HU Li-juan1 WEN Bin2 ZHOU Fu-sheng2 HUANG Shao-gang2 HUANG Sui-ping2 1. Guangdong Provincial TCM Hospital 2. Guangzhou University of Traditional Chinese Medicine;Effects of "Liandai Tablet" on Telomerase Activity and hTERT mRNA Expression in Nude Mice of Colonic Cancer[J];Shanghai Journal of Traditional Chinese Medicine;2008-08
7 WANG Yi,FANG Mei-yun,JIANG Feng. The First Affiliated Hospital of DaLian Medical University,Dalian,116011;Inhibitory Effects of Arsenic Trioxide,Ginseng Saponin and Elemol Combined with CTX on Telomerase in K562 Cell Line[J];The Practical Journal of Cancer;2004-05
8 HE Zhi-xu,XU Wei(Department of Pediatrics,the Affiliated Hospital of Guiyang Medical College,Guiyang 550004,Guizhou Province,China);Study Progress of Mechanism of Acute Leukemia in Children[J];Journal of Applied Clinical Pediatrics;2011-15
9 Zhang Yuhong, Zhu Yuzhen, Wang Xuexi Integrated Traditional Chinese and Western Medicine Institute of Lanzhou Medical College, Lanzhou 730000, Gansu, China Zhao Jianxiong Beijing University of TCM, Beijing 100029, China;Experimental study of Fuzheng Yiliu decoction on telomerease activity of tumor cell[J];;2002-07
10 Zhi Qiang Meng~1 Wei Jian Guo~2 Er Xin Yu~1 Ming Zhi Song~1 Wen Xia Huang~1 ~1Department of Hepatology,Cancer Hospital of Shanghai Medical University,Shanghai 200032,China ~2Department of Radiation Treatment,Xinhua Hospital of Shanghai Second Medical University,Shanghai 200093,China;Inhibition of telomerase activity and induced apoptosis of liver cancer cell SMMC-7721 by drug serum of Jianpi Liqi herbs[J];World Chinese Journal of Digestology;2000-08
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 XU Jun, ZHANG Guo ling, ZHAO Ming. Shanghai Cancer Institute, Shanghai 200032, China;STUDY ON THE RELATIONSHIP BETWEEN THE EXPRESSION OF SERUM VEGF AND THE EFFECTS CHEMOTHERAPY AND THE PROGNOSIS OF OVARIAN CANCERS[J];TUMOR;2000-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved