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《Chinese Medical Journal of Metallurgical Industry》 2010-01
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The evaluation of efficacy of different combined chemotherapy regimen for advanced colorectal carcinoma

SHENG Miao-hua.Dpartment of Oncology Workers'Hospital,Xiangtan Iron and Steel Company,Xiangtan 411101  
Objective:To study the efficacy and toxicity of oxaliplatin,5-Fu and CF for advanced colorectal carcinoma.Methods:62 colorecta carcinoma patients were randomized into FOLFOX4 group(n=32)and regimen(n=30).All patients received four course of chemotherapy.The treatments were both repeated every 2 weeks.Results:The overall reponse rate of the group with oxaliplatin was 46.9%(15/32).The main toxicity was neurotoxicity.And the overall response rate of the group without oxalip-latin was 16.7%(5/30).Conclusions:Our results indicated that combined oxaliplatin and 5-Fu with CF regimen was effective for advanced eolorectal cancer.And this regimens was superior to that without oxaliplatin.
【CateGory Index】: R735.34
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1 SUN Yan1, GUAN Zhongzhen2, JIN Maolin3, et al. 1Chinese Academy of Medical Sciences Cancer Hospital, Beijing 100021, China2Cancer Center, Sun Yatsen University of Medical Sciences, Guangzhou 510060, China3Beijing Tumor Hospital, Beijing 100036, Chi;A multicenter randomized phase II trial of oxaliplatin in patients with advanced colorectal cancer[J];CHINESE JOURNAL OF CANCER;1999-03
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