Study on Molecular Recognition of Molecularly Imprinted Polymers with Anticholinergic Drugs as Templates
GUO Yu-shu1,XIE Jian-wei2,ZHANG Yi1(1.Navy General Hospital,Beijing 100037,China;2.Beijing Institute of Pharmacology & Toxicology,Beijing 100850,China)
OBJECTIVE To investigate the molecular recognition mechanism of molecularly imprinted polymer(MIP) and its influence factors.METHODS MIPs were prepared with anticholinergic drug neotropine as template,methacrylic acid(MAA) as functional monomer and trimethylolpropane trimethacrylate(TRIM) as crosslinker.The specific solid phase extraction of MIPs was investigated for anticholinergic drugs:neotropine,penequinine,bencynonatine and anisodine,chlorphenamine with different hydrogen-band groups.RESULTS The results showed that the recognition ability of MIPs was associated closely with the conditions of synthesis and experiment.The specific molecular recognition was observed for anticholinergic drugs and weak adsorption for anisodine and chlorphenamine.CONCLUSION The experiments reveal that the non-specific adsorption of MIPs could mainly result from the hydrogen-band of polar groups between MIPs and analytes.The steric shape complementary between analytes and the recognition sites of MIPs plays a key role in the molecular recognition progress.
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JIANG Xuhong~(1,2) TU Weiping~1 (1 Institute of Chemical Engineering,SCUT,Guangzhou 510640; 2 Department of Chemistry and Chemical Engineering,Zhongkai University of Agriculture and Technology,Guangzhou 510225);Research Progress in Preparation of Molecularly Imprinted Polymer Microspheres[J];Materials Review;2007-12 |
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ZHU Li,HU Xiaoling,GUAN Ping(Department of Chemistry,Northwest Polytechnic University,Xi'an 710072,China);Progress of Preparation and Characteristics of Molecularly Imprinted Polymeric Microspheres[J];Chinese Polymer Bulletin;2007-11 |
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PU Jia - zhi, TANG You - wen, HU Xiao - gang, HUANG Zhao - fa, YAN Jing - hui
(Department of Chemistry, South China Normal University , Guangzhou 510631, China; Department of Chemistry , Zunyi Medical College, Zunyi 563003, China);Synthesis of molecular imprinting polymer for Nicotinic acid[J];West China Journal of Pharmaceutical Sciences;2004-02 |
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;Progress on the application of molecular imprinting polymers[J];Acta Academiae Medicinae CPAPF;2007-03 |
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