Application of Metoprolol Molecularly Imprinted Polymers to Solid Phase Extraction
HE Jian-feng 1,DENG Qin-ying 2(1.College of Chinese Traditional Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,China;2.School of Chemistry and Chemical Engineering,Sun Yat-san University,Guangzhou 510275,China)
OBJECTIVE To study the molecular recognition properties of the molecularly imprinted polymer(MIP) as the adsorbent of solid-phase extraction(SPE).METHODS The SPE columns were filled with metoprolol-molecularly imprinted polymers which were prepared by adopting molecular imprinting technique.By contrast with the blank polymer,the maximum loading capacities of MIP under the non-equilibrium conditions were investigated and the optimum models concerning on the loading,washing and elution solution were founded.RESULTS The metoprolol-imprinted extraction column exhibited high selectivity and good recognition ability for the template,howerver the blank polymer didn′t.Under the optimum extraction conditions,metoprolol and its structurally related compounds carvedilol and propranolol were separated primely on this kind of solid-phase column.CONCLUSION MIP,as the adsorbent of SPE,will provide an effective way to solve the purification of drugs.
【Key Words】：
metoprolol molecular imprinting technique solidphase extraction optimum conditions
【Fund】： 国家教育部博士点基金(20020558026);; 广州中医药大学创新基金(K0050035)
【CateGory Index】： R914
【Fund】： 国家教育部博士点基金(20020558026);; 广州中医药大学创新基金(K0050035)
【CateGory Index】： R914
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
| 【Co-references】 | ||
|
|||||||||||||||||||||
|
|||||||||||||||||||||