Study on Preparation of Imatinib Mesylate-MIP and Its Selective Recognition Ability

ZHOU Jun,RAO Yue-feng,WU Bao-hua(The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China)  

OBJECTIVE To establish a selective isolation method of imatinib mesylate using molecular imprinting technology.METHODS The molecular imprinted polymer(MIP) was synthesized by bulk polymerization using imatinib mesylate as the template.The MIP was investigated for its recognition of imatinib mesylate by equilibrium absorption and solid-phase extraction.RESULTS The MIP had specific absorbability to Imatinib mesylate.CONCLUSION The MIP prepared in the study can be used for selective recognition and isolation of imatinib mesylate analogues from natural products.

【Key Words】： imatinib mesylate molecularly imprinted polymers selective recognition bulk polymerization
【CateGory Index】： O631.3

Download(CAJ format) Download(PDF format)

CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.