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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-04
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Expression of CyclinD1 and CyclinE in squamous cell carcinoma of maxillary sinus and their significance

WANG Jian bo,WANG Ying (Department of Otorhinolaryngology,Jinning First People's Hospital,Shandong 272111,China)  
Objective To investigate the clinicopathlogical significance of the CyclinE and CyclinD1expression in squamous cell carcinoma of maxillary sinus.Methods The expression of CyclinE and CyclinD1 was examined by immunohistochemical method in inflammatory mucosa of maxillary sinus (10), inverting papilloma of maxillary sinus (20) and squamous cell carcinoma of maxillary sinus (50). Results In inflammatory mucosa of maxillary sinus, inverting papilloma of maxillary sinus and squamous cell carcinoma of maxillary sinus,the positive immunostaining rate of CyclinD1 protein was 10.0%,25.0% and 48.0% respectively( P 0.05)and that of CyclinE protein was 20.0%,35.0% and 58.0% respectively( P 0.05).There was no significant difference between the clinical types, T stage and clinical stage of carcinoma of maxillary sinus and the expression of CyclinD1 and CyclinE ( P 0.05).Conclusion With the development of lesions the positive immunostaining rate of CyclinE and CyclinD1 protein increases.The abnormalities of cell cycle regulators play an important role in the squamous cell carcinoma of maxillary sinus.
【CateGory Index】: R739.6
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Jianbo 1 LOU Weihua 2 DONG Mingmin 2 ( 1 Department of Otolaryngology,the First People′s Hospital,Jining 272111; 2Department of Otolaryngology,the First Affiliated Hospital,Henan Medical University);Study on the relation between the cell cycle regulators and laryngeal carcinogenesis[J];临床耳鼻咽喉科杂志;2001-03
2 Wang Jianbo;Clinicopathological significance of Cyclin E expression in laryngeal carcinogenesis[J];耳鼻咽喉头颈外科;2000-01
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 WANG Jian bo,WANG Ying (Department of Otorhinolaryngology,Jinning First People's Hospital,Shandong 272111,China);Expression of CyclinD1 and CyclinE in squamous cell carcinoma of maxillary sinus and their significance[J];中国肿瘤临床与康复;2004-04
2 WANG Jian-bo *, WANG Ying. *Department of Otorhinolaryngology, Jining First People′s Hospital, Shandong Jining 272111,China;Expression of cell cycle regaltors in squamous cell carcinoma of maxillary sinus and their significance[J];中华耳鼻咽喉科杂志;2003-06
3 WANG Jian bo, GAO Fu ping, ZHANG Xiu lan,et al. Department of Otorhinolarygology,Jinning First People′s Hospital,Jining 272111,China;Clinicopathological significance of CyclinA and CyclinB_1 expression in laryngeal carcinogenesis[J];中国肿瘤临床与康复;2002-04
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