Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-04
Add to Favorite Get Latest Update

A clinical study of tropisetron hydrochloride injection in the prevention of nausea and vomiting induced by NVB+PDD in the treament of NSCLC

WANG Hong yu,ZHANG Xiang ru,SUN Yan,et al (Cancer Institute & Hospital,Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021,China)  
Objective To study the efficacy and safety of tropisetron hydrochloride injection(THI) in prevention of PDD and NVB induced nausea and vomiting in comparison with Navoban in the treatment of NSCLC.Methods In a multicenter randomised double blind crossover study comparing THI and Navoban, 110 patients were enrolled.THI or Navoban was administered before the first cycle of chemotherapy, and changed to the other antiemetic agent in the second cycle of the same chemotherapy.Results 109 patients were evaluated for adverse effects and 100 were evaluated for response.The complete control of anorexia by THI was 74.0%,55.0%, 34.0% ,25.0%,31.0% and 56.0% respectively during d1 6,while that by Navoban was 77.0%,56.0%, 40.0% ,26.0%,37.0% and 56.0% respectively;the complete control of nausea by THI was 73.0%,45.0%,28.0%,17.0%,25.0% and 47.0% respectively while that by Navoban was 70.0%,47.0%,25.0%,16.0%,25.0% and 49.0% respectively;the complete control of vomiting by THI was 94.0%,72.0%,58.0%,51.0%,66.0% and 88.0% respectively,while that by Navoban was 87.0%,75.0%,55.0%,53.0%,67.0% and 80.0% respectively.The complete control of anorexia,nausea and vomiting showed no significant difference between THI and Navoban, P 0.05.The most frequent adverse events were similar,and had no significant difference between the two antiemetic agents( P 0.05).Conclusion Tropisetron hydrochloride injection was similar to Navoban for the prevention of PDD and NVB induced nausea and vomiting in the treatment of NSCLC. It was safe and effective in control of anorexia nausea and vomiting induced by highly emetogenic drugs.Its adverse effects were mild and could be well tolerated.
【CateGory Index】: R734.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 4 Hits
1 Cao Qijun;Wang Haixia;Department of Internal Medicine,Cixi Municipal People's Hospital of Zhejiang Province;;The effect of tropisetron combined with sulpiride on chemotherapy-induced cisplatin program nausea and vomiting[J];中国医师进修杂志;2014-18
2 ZHANG Ming-zhi,HE Zhen,LI Xin(Department of Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China);Clinical study of tropisetron hydrochloride injection in the prevention of nausea and vomiting induced by CHOP regimen in the treatment of NHL[J];现代医药卫生;2006-20
3 LI Zi-hui,ZHOU Li-zhong(Department of Radiology,The Forth Hospital of Anshan City,Anshan 114033,China);A randomized,double blind,crossover clinical study of tropisetron hydrochloride injection for the prevention of nausea and vomiting induced by NVB+PDD[J];中国新药杂志;2005-10
4 HUANG Haihui,LIANG Houjie(Dept.of Oncology,The Southwest Hospital of the Third Military Medical University,Chongqing400038,China) WANG Donglin(Dept.of Oncology,The Xinqiao Hospital of the Third Medical Military University,Chongqing400037,China) CHEN Xiaopin(Dept.of Oncology,The First Affiliated Hospital of Chongqing University of Medical Sciences,Chongqing400016,China) CHEN Xiaoyong(The Chongqing Human Academy of Pharmacy,Chongqing400041,China);Evaluation on the Curative Effects and Safety of the Domestic Tropisetron Hydrochloride on Cisplatin-induced Nausea and Vomiting[J];中国药房;2005-17
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZOU Yan-mei,XIONG Hua,HU Guang-yuan(Cancer Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China);Palonosetron Hydrochloride Injection in Prevention of Moderate to Severe Chemotherapy-induced Nausea and Vomiting[J];医药导报;2013-04
2 BAI Hong-mei, SUN Jian-hua, ZHANG Jie.Department of Anesthesiology, Jiangsu Province Traditional Chinese Medicine Hospital, Nanjing 210029, China;Effect of electroacupuncture combined with tropisetron in treating postoperative nausea and vomiting in patients undergoing total hysterectomy[J];临床麻醉学杂志;2012-12
3 QIU Li-hua~*, WANG Hua-qing,YU Zhuang,LI Li,WANG Xiang-hui,WANG Shun-jin,SUN Guo-ping,LIU Min, ZHANG Shu-cai.* Department of Medical Oncology,Affiliated Cancer Hospital,Tianjin Medical University, Tianjin 300060,China;Efficacy and safety of palonosetron versus tropisetron in the prevention of highly emetogenic chemotherapy-induced acute and delayed vomiting in Chinese cancer patients[J];中华医学杂志;2011-36
4 WANG Hong yu,ZHANG Xiang ru,SUN Yan,et al (Cancer Institute & Hospital,Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021,China);A clinical study of tropisetron hydrochloride injection in the prevention of nausea and vomiting induced by NVB+PDD in the treament of NSCLC[J];中国肿瘤临床与康复;2004-04
5 SUN Ya-hong, ZHANG Bao-xuan, GUO Qi-sen, et al. Department of Medical Oncology, ShanDong Tumor Hospital, Jinan 250117;The Effect of Ondansetron and Azasetron was Compared in Prevention of Nausea and Vomiting Induced by Anti-Cancer Drugs[J];临床肿瘤学杂志;2004-01
6 LEI Wei,ZHU Jingjuan,LIANG Jun(The Affiliated Hospital,of Qingdao Medical College of Qingdao Uniˉversity,Qingdao266003);The Clinical Effect and Cost-effectiveness Analysis of Granisetron and Ondansetron in the Prevention of Nausea and Vomiting Induced by Cisplatin[J];中国药房;2003-06
7 ZHU Ming-wei CAO Jin-duo ZHU Xue-guang WANG Yu ZHAO Xu WEI Jun-ming SUN Qing-yun ( Department of General Surgery, Beijing Hospital, Beijing, 100730) ( Department of General Surgery, Peking University People's Hospital, Beijing, 100044) ( Department of General Surgery, Beijing Friendship Hospital, Beijing, 100053);The Randomized Controlled Multicenter Clinical Study of Tropisetron to The Patients with Nausea and Vomiting after Abdominal Operation[J];中国临床药理学杂志;2003-02
8 LU Zi-min,GU Feng-ying.Tongji Hospita of Tongji university,Shanghai 200065,China;The Effect of Ondansetron and Meocloprarnide was Compared in the Prevention of Emesis[J];肿瘤防治杂志;2002-05
9 Shi Yonggang Fan Riutai Wu Chaogang et alDepartment of Radiotherapy, First Affiliated Hospital of Henan Medical University, Zhengzhou;Tropisetron in Prevention of Vomiting Induced by Peritoneal Perfusion with Heated Cisplatin[J];中国肿瘤临床;2000-06
10 Xu Nong Cai Jufen Yu Xinmin Zhejiang Cancer Hospital, Hangzhou$$$$;Single-dose Tropisetron for Prevention of Cisplatin-induced Emesis[J];中国肿瘤临床;1999-09
【Secondary References】
Chinese Journal Full-text Database 7 Hits
1 SUN Yong-tao,ZOU Ting,LI Rong,YUE Qing-zhu,LI Jing,WANG Wen,YANG Jun,XI Fei-fei.Department of Anesthesia,Jinan fourth People's Hospital,Jinan 250031,China;The evaluation of butorphanol and lappaconite versus butorphanol alone for PCIA post gynecological surgery[J];中国临床研究;2012-07
2 BAI Xian-ling ZHANG Hui(Dept.of Gynecology,Affiliated Hospital of Taishan Medical College,Taian 271000,China);Clinical analysis of adverse reactions of two regimens in the treatment of cervical cancer[J];泰山医学院学报;2012-06
3 WANG Jun,LU Ai-xia Department of Oncology,Tai'an central hospital,Shandong 271000,China;Palonosetron hydrochloride for chemotherapy-induced nausea and vomiting in hepatocellular carcinoma treated with TACE[J];社区医学杂志;2012-08
4 ZHANG Yu-ting,ZHAO Chun-quan(Dept.of Gynecology and Obstetrics,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China);Clinical Study of Neoadjuvant Chemotherapy Drugs for Cervical Cancer[J];中国药房;2010-46
5 Ma Zongbin(Affiliated Hospital of North Sichuan Medical College,Sichuan,Nanchong 637000,China);Therapeutic Effect of Pantoprazole Combined With Tropisetron on Prevention of Adverse Drug Reaction Caused by Chemotherapy[J];中国药师;2009-06
6 YANG Yun,LI Rong,LI Xue-lian,YUE Qing-zhu,LI Jing,SUN Yong-tao,DENG Li-qiang,GUO Feng.Department of Anesthesiology,The Fourth People's Hospital,Jinan 250031,China;Control study on analgesic effect comparing butorphanol to fentanyl after cesarean section[J];中国厂矿医学;2009-02
7 CHEN Jie,GAN Jianhui(Dept.of Anesthesiology,Hebei Provincial Tangshan People's Hospital,Tangshan063000,China);Tropisetron in the Prevention of Postoperative Nausea and Vomiting Induced by Patient-Controlled Epidural Analgesia in Gynopathic Patients:Observation of Curative Effects[J];中国药房;2006-13
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved