Treatment of recurrent or refractory non Hodgkin′s lymphoma with combined chemotherapy based on home made navelbin
WANG Jian feng,HUANG Xue zhen,CHEN Ying (Department of Oncology,Fujian Cancer Hospital,Fuzhou 350014,China)
Objective To evaluate the therapeutic effectiveness and side effects of combined chemotherapy with home made vinorelbine(NVB) in the treatment of recurrent or refractory non Hodgkin′s lymphoma. Methods 30 mg/m 2 NVB was infused by ivgtt on d1,5;and 30 mg/m 2 DDP by iv drip on d1 3;100 mg/m 2 Ara c by iv drip on day 1 2;60 mg/m 2 PDN orally on d1 5.Three weeks constituted one cycle.Results The total response rate(CR+PR) was 72.2% with 2 CR and 11 PR.Drug related toxic effects of chemotherapy were mild gastrointestinal reactions in most patients and severe bone marrow depression in a few patients.Conclusion These results indicate that the combined chemotherapy with domestic NVB is effective in the treatment of recurrent or refractory non Hodgkin′s lymphoma.This protocol is worthy to be confirmed as a salvage for recurrent or refractory non Hodgkin′s lymphoma.
【CateGory Index】： R733.1