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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
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Cellular immunity status of untreated patients with nasopharyngeal carcinoma and evaluation of examining parameters

ZHANG Yu-jing,CHEN Yu-biao,XIA Yun-fei,et al (Department of Radiation Oncology,Cancer Center,Sun Yat-sen University,Guangzhou 510060,China)  
Objective To determine the cellular immunity status by examining multiple parameters in untreated patients with nasopharyngeal carcinoma,and to evaluate the validity of each parameter.Methods Peripheral venous blood samples of 105 patients were analyzed with flow cytometry and 3H-TdR release test between March and December 2003 to determine the parameters including T lymphocyte subsets and activation level,B lymphocyte,NK,and LAK activity.The correlation of the parameters was analyzed in relation with the clinical stage of the tumor and HBV infection.Results According to 1992 staging scheme,the tumors were at stage Ⅰ in 6 patients,stage Ⅱ in 21 patients,stage Ⅲ in 48 patients,stage IVa in 30 patients.Blood BUN and Cr were roughly normal,with no HIV infection.CD8+ showed a significant correlation with tumor stage(r=0.218,P= 0.013) and the parameters that showed significant close correlations with tumor stage included CD4+/CD8+ ratio(P=0.051),CD8+CD25+(P=0.059),and LAK activity(P=0.057).Tumor stage showed relationship with HBsAg presence (r=0.220,P=0.012).After excluding the cases with HBV infection,the parameters that showed significant correlations with tumor stage included CD4+(r=-0.253,P=0.025),CD8+(r=0.284,P=0.013),CD4+/CD8+ ratio(r=-0.346,P=0.003),B lymphocyte(r=-0.221,P=0.043),and CD8+CD25+(r= -0.436,P=0.000).Conclusion The cellular immunity suppression in untreated patients with nasopharyngeal carcinoma is related with the clinical tumor stage,and can be influenced by HBV infection.Determining parameters of CD4+,CD8+,CD4+/CD8+ ratio,CD8+CD25+,and LAK activity,can be valid.
【CateGory Index】: R739.63
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