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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
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Clinical application of measuring the serum laminin in patients with colorectal cancer

YIN Dong,WANG Hai-jiang,GUI Xia,et al (Affiliated Tumor Hospital, Xinjiang Medical University,Urümqi 830011,China)  
Objective To investigate the changes of serum contents of laminin (LN) in preoperative and postoperative patients with colorectal cancer and its value in diagnosis and prognosis of the cancer,and to evaluate the clinical significance of serum LN in neoplastic relapse and metastasis as compared with CEA and CA 242. Method The contents of LN, CEA and CA 242 in serum were measured by radioimmunoassay in patients with colorectal cancer.Results In 44 colorectal cancer patients,the specificity,sensitivity and accuracy of serum LN in diagnosis of the cancer were 84.1%,92.7% and 89.3% respectively.The contents of serum LN in all cancer groups of different Dukes stages were significantly higher than those in control group and benign disease group (P0.05). There was no difference between control group and benign disease group (P0.05). The contents of LN in Dukes C and D were higher than those in Dukes A and B(P0.05).The content of LN in postoperative group was lower than that in preoperative group (P0.05).In all patients with colorectal cancer, the positive rate of LN was higher than those of CEA and CA 242(P0.05).Conclusion Serum LN is helpful to diagnosis, judgment of prognosis and instructing clinical therapy of colorectal cancer.
【CateGory Index】: R735.34
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Feng Shu, Song Jindan (Department of Cell Biology, School of Basic Medical Sciences, China Medical University, Shenyang, 110001);Expression of Endoplasmic Reticulum Synthesized Laminin in Colorectal Carcinomas[J];JOURNAL OF CHINA MEDICAL UNIVERSITY;1997-04
2 Bao Xiusheng Bao Jiangping The central Hospital of Jiang Han oil Field,Qianjiang 433124;The dinical use value of the serum laminin protein[J];CANCER RESEARCH ON PREVENTION AND TREATMENT;1999-01
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 Zhao Junli, Wang Shuyu, Zheng Yiling, et al. Department of Gynecology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029;The Expression and Significance of Laminin of Three Different Endometrium[J];ACTA ACADEMIAE MEDICINAE NANJING;2000-03
2 YIN Dong,WANG Hai-jiang,GUI Xia,et al. Affiliated Tumor Hospital,Xinjiang Medical University,Xinjiang,830011;Dynamic Detection of the Serum Laminin in Preoperative and Postoperative Patients With Colorectal Cancer and its Clinical Significance[J];The Practical Journal of Cancer;2004-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Xin Tao, Fang Li PingDepartment of Oncology,The Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang, 150086,P.R.China;Study Progress of p73 Gene in Digestive System Carcinoma[J];Chinese Journal of Cancer;2004-01
2 Zhou Zhiqiu, Den Weijun, Chen Zhanbin, et al.Department of General Surgery, Shilong People's Hospital of Dongguan, Guangdong, 523321;Value of Early Diagnosis of Recurrence after Operations on Colorectal Carcinoma Through Serum CEA[J];Journal of Coloproctological Surgery;2004-01
3 CHEN Zi-hua,CHEN Zhi-kang.Department of General Surgery,Xiangya Hospital of Central South University,Changsha,410008,China;Evaluation of Carcinoembryonic Antigen (CEA) and Carbohydrate199 (CA199) Determination in Recurrence After Radical Colonic Cancer Surgery[J];Journal of Chinese Physician;2003-07
4 WANG Zhong-min,TANG Huai-hao,YANG Hong-wei,et al. Department of Cardiothoracic Surgery,The First Affliated Hospital of Xinxiang Medical College, Weihui 453100, China;A Clinical Study on the Expression of Cathepsin D and P Selectin in Human Non-small Cell Lung Cancer[J];Journal of Chinese Physician;2004-03
5 ZHANG Xin-min,WANG Jiao-chen. Department of Pathology, The Second Xiangya Hospital, Central South University,Changsha 410011,China;Expression of Collagenase Ⅳ and Collagen Type Ⅳ in Papillary Thyroid Carcinoma[J];Journal of Chinese Physician;2004-05
6 LI Ying-jia 1 ,WANGDong 2 ,ZHOUYa 3 Departmentsof Ultrasonography 1 andRespiratoryDiseases 3 ,NanfangHospital,FirstMilitaryMedicalUniversity,Guangzhou510515,China;2 Departmentof Pathology,DapingHospital,ThirdMilitaryMedic;Observation of the microstructure and ultrastructure of microvessels induced by OS -732cell line[J];Journal of First Military Medical University;2002-02
7 HUANG Cong-wu, BAI LanInstitute for Digestive Diseases of PLA, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China;Clinical value of carbohydrate antigen 50 and carbohydrate antigen 242 in the diagnosis of colorectal carcinoma[J];Journal of First Military Medical University;2002-12
8 YANG Fang, HE Yuan-li Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China;Recombinant human endostatin induces apoptosis of human umbilical venous endothelial cells[J];Journal of Southern Medical University;2006-07
9 AN Ping a,CAI Hui-yun b,QI Hong-feng a,ZHANG Yan a,LIU Jing a(a.Laboratory Center;b.Center of General Surgery of PLA,General Hospital of Beijing Military Area,Beijing 100700,China);Expression and Clinical Significance of Serum E-Selection in Colorectal Cancer Patients[J];Medical Journal of National Defending Forces in North China;2008-03
10 LI Ronghua,ZHANG Chen,WANG Bangmao,et al.Department of Oncology,The Third Hospital of Hebei Medical University,Hebei,Shijiazhuang 050051;A study on the change of the serum levels of soluble sCD44v6 and the expression of CD44v6 in the tissues of gastric tumor[J];Hebei Medical Journal;2006-05
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