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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
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Clinical application of measuring the serum laminin in patients with colorectal cancer

YIN Dong,WANG Hai-jiang,GUI Xia,et al (Affiliated Tumor Hospital, Xinjiang Medical University,Urümqi 830011,China)  
Objective To investigate the changes of serum contents of laminin (LN) in preoperative and postoperative patients with colorectal cancer and its value in diagnosis and prognosis of the cancer,and to evaluate the clinical significance of serum LN in neoplastic relapse and metastasis as compared with CEA and CA 242. Method The contents of LN, CEA and CA 242 in serum were measured by radioimmunoassay in patients with colorectal cancer.Results In 44 colorectal cancer patients,the specificity,sensitivity and accuracy of serum LN in diagnosis of the cancer were 84.1%,92.7% and 89.3% respectively.The contents of serum LN in all cancer groups of different Dukes stages were significantly higher than those in control group and benign disease group (P0.05). There was no difference between control group and benign disease group (P0.05). The contents of LN in Dukes C and D were higher than those in Dukes A and B(P0.05).The content of LN in postoperative group was lower than that in preoperative group (P0.05).In all patients with colorectal cancer, the positive rate of LN was higher than those of CEA and CA 242(P0.05).Conclusion Serum LN is helpful to diagnosis, judgment of prognosis and instructing clinical therapy of colorectal cancer.
【CateGory Index】: R735.34
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