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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
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Comparative study of AgNORs between lymphocyte chromosome and cancer tissue in lung cancer patients

CAI Shao-jing,ZHANG Zhao-lei (Department of Biology,Xuzhou Medical College,Xuzhou,Jiangsu 221002,China)  
Objective To study the correlation of nucleolar argentophil protein(AgNORs) between lymphocyte chromosomes and lung cancer cells.Methods AgNORs were examined by silver straining technique in 98 cases of lung cancer patients (adenocarcinoma 36;small cell cancer 31;squamous cell carcinoma 31) and 40 cases of the control group.Results (1)AgNORs counts of lymphocyte chromosomes in adenocarcinoma,small cell cancer and squamous cell carcinoma were 9.01±0.51,8.26±0.42 and 7.74±0.38,respectively,significantly higher than that in the control group(6.98±0.46,P0.01).(2)AgNORs counts of lung cancer cells in the 3 groups of lung cancer were 6.97±0.98,5.94±1.03 and 5.15±0.67, respectively,significantly higher than that of the normal cells(P0.01).(3)AgNORs counts of lymphocyte chromosomes and lung cancer cells in adenocarcinoma were significantly higher than those in small cell cancer, and those in small cell cancer were higher than those in squamous cell carcinoma.In the 3 groups of lung cancer,AgNORs counts of lymphocyte chromosomes were positively correlated with those of lung cancer cells and the correlation coefficients were 0.91,0.89 and 0.84,respectively(P0.01).Conclusion AgNORs counts of lymphocyte chromosomes and lung cancer cells in lung cancer were parallel to chromosome instability.Hence,AgNORs count of lymphocyte chromosomes has important significance for judging histological type of lung cancers.
【CateGory Index】: R734.2
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Chinese Journal Full-text Database 10 Hits
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