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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
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Function and clinical application of Huaier plaster in comprehensive therapy of breast cancer

ZHANG Yu-bao,ZHANG Guo-qiang,WANG Jin-song,et al (Department of Surgery,the Tumor Hospital of Harbin Medical University,Harbin 150040,China)  
Objective To explore the function of the Jinke-huaierkeli plaster in the comprehensive therapy of breast cancer and the mechanism.Methods MTT method was used to detect the cytotoxicity of the drug,drug-resistant multiple and reversing multiple.Fluorescent spectrophotometer was used to measure the concentration of ADM in cells and fluorescent quantitative PCR method was used to detect the effect of the drug on the expressing level of MDR-1 mRNA in cells.Results (1) 0.01 mg/ml Huaierkeli plaster can significantly reduce the IC 50( 3.95 μg/ml) of ADM to the drug-resistant cell strain (MCF-7/A) of breast cancer,with significant difference as compared with the IC 50( 17.67 μg/ml) to the drug-resistant cell strain MCF-7/A without reversing(P0.05).Its reversing multiple was 4.5 times and drug-resistant multiple was 21.7 times.(2) 0.01mg/ml Huaierkeli plaster could significantly increase the concentration of ADM in drug-resistant cells,with significant difference(P0.01).(3) MDR-1 mRNA was not expressed in the sensitive cell strain MCF-7/S of human breast cancer.The Huaierkeli plaster at dosages of low toxicity or without toxicity lowered the expressing level of MDR-1 in MCR-7/S with significant difference as compared with the control(P0.01).Conclusions This research indicate that Jinke-huaierkeli plaster can increase the sensitivity of breast cancer cells to chemotherapy drug.Its mechanism is that it can lower the expressing level of the drug-resistant gene MDR-1 and reverse the drug-risistance.At the same time the research preliminarily indicates that Jinke plaster has two effects,one is the anti-tumor activity and the other is reverse the drug-resistance.
【CateGory Index】: R737.9
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