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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
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Treatment of malignant pleural effusion using 5-Fu and MMC injection into pleural cavity in the elderly

XIONG Bing, CHEN Jie,LI Wan-cheng,et al (Department Respiratary Medicine,Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China)  
Objective To evaluate the efficacy of 5-fluorouracil (5-Fu) and mitomycin (MMV) injection into pleural cavity in treating malignant pleural effusion.Methods Thirty-seven old patients with malignant pleural effusion were divided randomly into 2 groups.5-Fu 750 mg/m2 and MMC 8 mg/m2 were injected into pleural cavity in therapy group(T),and only cisplatin (DDP) 40 mg/m2 was given in control group (C).The injection was given once 3 to 5 days for 3 to 5 times successively.Then the efficacy,toxicity and quality of life were evaluated.Results The response rate was 75.0% in T group and 70.6% in C group.There was no statistical difference betwee two groups (P0.05),The Karnofsky score was higher in T group than in C group(P0.05).Myelosuppession,nausea and vomiting were significantly lower in T group than in C group (P0.05).Conclusion The treatment with 5-Fu and MMC is a safe,and well tolerable method with little side effects for treating malignant pleural effusion in the elderly.
【CateGory Index】: R734.2
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