Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
Add to Favorite Get Latest Update

Treatment of malignant pleural effusion using 5-Fu and MMC injection into pleural cavity in the elderly

XIONG Bing, CHEN Jie,LI Wan-cheng,et al (Department Respiratary Medicine,Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China)  
Objective To evaluate the efficacy of 5-fluorouracil (5-Fu) and mitomycin (MMV) injection into pleural cavity in treating malignant pleural effusion.Methods Thirty-seven old patients with malignant pleural effusion were divided randomly into 2 groups.5-Fu 750 mg/m2 and MMC 8 mg/m2 were injected into pleural cavity in therapy group(T),and only cisplatin (DDP) 40 mg/m2 was given in control group (C).The injection was given once 3 to 5 days for 3 to 5 times successively.Then the efficacy,toxicity and quality of life were evaluated.Results The response rate was 75.0% in T group and 70.6% in C group.There was no statistical difference betwee two groups (P0.05),The Karnofsky score was higher in T group than in C group(P0.05).Myelosuppession,nausea and vomiting were significantly lower in T group than in C group (P0.05).Conclusion The treatment with 5-Fu and MMC is a safe,and well tolerable method with little side effects for treating malignant pleural effusion in the elderly.
【CateGory Index】: R734.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LIU Su-qin, ZHOU Tao, SUN Liang-xin (Department of Oncology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China);Small-bore catheter drainage and bi-platin intraplueral chemotherapy in treatment of patients with malignant pleural effusion[J];Journal of Dalian Medical University;2003-02
2 ZHANG He-Long 1, WANG Wen-Liang 2, MIN Jie 1 1Department of Oncology, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China, 2Department of Pathology, Faculty of Preclinical Medicine, Fourth Military Medical University;Detection of mutant p53 gene in pleural effusion cells with PCR-SSCP[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;2000-07
3 ZHU Yunzhong , SHI Heling, QIAN Hao, HUANG Wenxia, HONG Zhuan, ZHANG Yiping, XU Nong, ZHANG Li, LIU Donggeng, DONG Zhongsheng, LI Shufen, ZHANG Lijian, ZHENG Wen. Beijing Thoracic Tumor Research Institute, Beijing 101149, P.R.China;The phase Ⅱ clinical trial of Seratia Marcescens Anticancer Vaccine (S311)for malignant pleural effusions[J];Chinese Journal of Lung Cancer;2001-04
4 ZHANG Li, LI Longyun, LI Huai, ZHOU Chunwu. Department of Respiratory Diseases, Peking Union Medical College Hospital, CAMS and PUMC, Beijing 100730, P.R.China;Clinical significance of tumor markers in the diagnosis of lung cancer[J];Chinese Journal of Lung Cancer;2002-03
5 Shi Zhiyan, Luo Yong, Meng Jiahui. Lingshan County Hospital of TCM Guangxi Zhuangzu autonomous region,535400;Clinical effect of Fufang Danshen injection integrated with CF by thoracic injection on malignant ascites[J];Hebei Journal of Traditional Chinese Medicine;2001-04
6 CHEN Chao-qin, ZHENG Zhong-sheng, ZHENG Xiao-he, et al (Department of pulmonary disease, 1st Affiliated Hospital of Shantou University Medical college, Guangdong Shantou 515041, China);Immediate effect of N-CWS in treatment of malignant pleural effusion in pulmonary carcinoma[J];Hebei Medicine;2003-03
7 MA Yao-xian,LIU Run-sen,ZHAO Hong-liang (Xuchang Central Hospital,Xuchang 461000,China);rhTNF-NB and Cisplatin Combined Therapy in the Treatment of Malignant Pleural Effusion:A Report of 38 Cases[J];Henan Journal of Oncology;2002-05
8 KANG Yan-zhi,REN Hui-juan (Heze Municipal Tumor Hospital, Heze 274029,China);Combination of Cisplatin,5-Fu and Chemotherapy Treating 30 Cases of Malignant Pleural Effusion[J];Journal of Heze Medical College;2002-01
9 First people hospital of Hefei Zhang Shu Pin, Li Xiu , Zhang Ying;Diagnosis significance on the integration of mesothelial cell count in pleural cavities accumulative fluid and pleurae histic examination for identifying benignant or malignant pleural cavities fluid.[J];Journal of Clinical Pulmonary Medicine;2002-04
10 Wang Suping Zhu Yaling Zhang Yinming et al Chest Hospital of Nanjing City, Nanjing 210029;Outcome Analysis of the Treatment of Malignant HydrothoraxWith a Combined Method of Radio Frequency Hyperthermia and Chemotherapy[J];Journal of Clinical Pulmonary Medicine;2003-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved