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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
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Factors in fluencing prognosis of treatment of brain metastases with X-knife radiosurgery

HUA Qing-yun,LIU Xian-hua (Xuzhou Third People's Hospital of Jiangsu Province,Xuzhou 221005,China)  
Objective To explore the factors influencing prognosis of patients after treatment of brain metastases with X-knife radiosurgery.Methods Sixty-one patients with 79 lesions of brain metastases of treated with X-knife radiosurgery were analysed retrospectively. The diameters of the brain metastases were(2.07±1.7)cm, the mean dose of X-knife given was 22 Gy, the doses of central parts of the tumors were(28±8)Gy.The primary sites of cancers were lung in 34 patients,kidney in 5 cases, breast in 9 cases, alimentary system in 13 cases.The patients′ ages were from 31 to 74 years(median 58.7 years) and the male/female ratio was 1.2∶1. The median follow-up period was 12 months (range 1-23 months) and median survival time was 44 weeks.Results Six-month and 1-year survival rates were 68.9% and 36.1%,respectively. Karnofsky Performance Scale score≥70 median survival time was 46 weeks and median survival time of single tumor volume≤8.2 cm3 was 58 weeks. The 1-year actual local control rate was 83.0%.In multivariate analysis smaller volume was associated with better control.Conclusions Karnofsky Performance Scale score,controlled primary cancer and absence of extracranial metastases were associated with long survival time. In addition tumor volume was a statistically significant factor for local control.
【CateGory Index】: R739.4
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 LIU Xian-hua,YU Xiao-liang,HUA Qing-yun,et al.Xuzhou Third People's Hospital,Xuzhou 221005,China;Clinical Report about Treatment of Lung Cancer and Their Cerebral Metastases by X-Knife Radiosurgery[J];Journal of Qilu Oncology;2003-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LIU Xian hua,HUA Qing yun,YU Xiao liang,et al.XuZhou Third People's Hospital,Xuzhou 221005;The experience about X-Knife radiosurgery therapeutic introcranial malignant neoplasms in 32 patients[J];JOURNAL OF QILU ONCOLOGY;2000-02
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