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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
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Efficacy of ifosfamide and Vp-16 in chemotherapy of 41 cases of small cell undifferentiated lung cancer

WANG Si-wen1,WANG Si-yang2,LI Yu3 (1.Department of Internal Medicine, Central Hospital, Shenyang Railway Bureau, Shenyang 110032,China; 2.Staff Hospital, Shenyang Airplane Design and Research Institute; 3.Department of Thoracic Surgery, First Affiliated Hospital,China Medical University)  
Objective To observe the efficacy of ifosfamide and Vp-16 in chemotherapy of small cell undifferentiated lung cancer,and investigate the adverse effect and factors affecting the prognosis.Methods Forty-one cases of small cell undifferentiated lung cancer received chemotherapy with ifosfamide and Vp-16, hydration by Mesna and normal saline.Results Complete remission (CR) was found in 28 cases (68.3%) and partial remission (PR) in 10 (24.4%), with the total remission rate of 92.7% (38/41), progression of disease (PD) in 3 cases (7.3%). Two patient survived for more than 5 years, 5 cases over 3 years.Different levels of bone marrow suppression were observed in 13 cases,renal damage in 2 cases,hepatic damage in 3 cases, whose functions were restored to normal after the interval period and symptomatic therapy.Conclusion Chemotherapy with the combination of ifosfamide and Vp-16 is in accordance with the need of large dose and combined use of chemicals for small cell undifferentiated lung cancer and showed satisfactory results and mild adverse effect.
【CateGory Index】: R734.2
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