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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
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High-dose toremifene plus EP regimen in the treatment of refractory advanced non-small cell lung cancer

CAO Xiao-long1,XU Guang-chuan2,CAI Xiao-ling1,et al (1.Department of Oncology,Pan Yu People's Hospital,Guangzhou 511400,China; 2.Department of Medicine,Cancer Center,Sun-Yat-Sen University,Guangzhou 510060,China)  
Objective To evaluate the efficacy and safety of high-dose toremifene plus EP regimen in the treatment of refractory advanced non-small cell lung cancer (NSCLC).Methods The patients with previously DDP-resistant advanced NSCLC were treated with high-dose toremifene (480 mg,po,d1-7.5)plus EP regimen C (Vp-16 100 mg/m2 iv d4-6,DDP 80 mg/m2 iv d4) every 4 weeks.Results A total of 50 cases with advanced NSCLC resistant to DDP were enrolled,and 43 cases were valuable for efficacy assessment.One patient reached complete response (CR),8 reached partial response (PR),and the overall response rate was 20.9% (with ITT equal to 18.0%).The median survival time and the median progression-free survival time was 8.1 and 3.2 months respectively and 1-year survival rate was 37.2%.The major adverse effects were mild myelosuppression,nause and vomiting.Conclusions The high-dose toremifene plus EP regimen is effective in the treatment of advanced NSCLC resistant to DDP,and the adverse effects were tolerable.
【CateGory Index】: R734.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 CAO Xiao-long~1, MAO Zhi-da~2, HU Jia-zhu~1, GUO Tian-sheng~1, HUANG Fu-xi~1, ZHANG Li~21.Department of Oncology,Panyu Peoples' Hospital, Guangzhou 511400, P.R.China2.Department of Medicine, Cancer Center, Sun-Yat-Sen University, Guangzhou 510060,P.R. China;Comparison of high-dose toremifene plus EP regimen versus docetaxel alone in the second-line treatment of advanced non-small cell lung cancer[J];肿瘤防治杂志;2005-24
【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Xueyan, LI Qiang,HAN Yiping, LIU Zhongling. Department of Respiratory Medicine, Chang Hai Hospital, Second Military Medical University, Shanghai 200433, China;Synergistic effect of toremifene and cisplatin on human lung cancer cell line A549[J];中华肿瘤杂志;2002-06
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 Xia Yunhong1,Zhang Canzhen2,Ma Liju3,Wang Qinqin3(1.Department of Oncology,the Second People's Hospital of Huaian,Huai'an 223002,China;2.Department of Oncology,the Third Affiliated Hospital of Kunming Medical College,Kunming 650106,China;3.Center for Clinical Trials,the First Affiliated Hospital of Kunming Medical College,Kunming 650032,China);Synergistic Effects of Toremifene and Cisplatin on Inhibiting Human Lung Cancer Cell Line GLC-82 Growth[J];肿瘤基础与临床;2009-05
2 ZHANG Xing-hua,LIU Ji-cheng,AN Chang-shan.The Second Hospital of Daqing City,Heilongjiang 163461,China;Synergistic Effect of the Combination of Toremifene with Gemcitabine on Growth and Apoptosis in Human Lung Cancer Cell Line A549[J];中国自然医学杂志;2008-03
3 CAO Xiao-long~1, MAO Zhi-da~2, HU Jia-zhu~1, GUO Tian-sheng~1, HUANG Fu-xi~1, ZHANG Li~21.Department of Oncology,Panyu Peoples' Hospital, Guangzhou 511400, P.R.China2.Department of Medicine, Cancer Center, Sun-Yat-Sen University, Guangzhou 510060,P.R. China;Comparison of high-dose toremifene plus EP regimen versus docetaxel alone in the second-line treatment of advanced non-small cell lung cancer[J];肿瘤防治杂志;2005-24
4 CAO Xiao-long1,XU Guang-chuan2,CAI Xiao-ling1,et al (1.Department of Oncology,Pan Yu People's Hospital,Guangzhou 511400,China; 2.Department of Medicine,Cancer Center,Sun-Yat-Sen University,Guangzhou 510060,China);High-dose toremifene plus EP regimen in the treatment of refractory advanced non-small cell lung cancer[J];中国肿瘤临床与康复;2004-06
5 Cheng Guangyuan (Department of Radiation Oncology, Anhui Provincial Hospital, Hefei 230001, China);Strategy of multidrug resistance and drug-resistance reversion in lung cancer chemotherapy[J];癌症进展;2003-01
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 CAO Xiao-long1,XU Guang-chuan2,CAI Xiao-ling1,et al (1.Department of Oncology,Pan Yu People's Hospital,Guangzhou 511400,China; 2.Department of Medicine,Cancer Center,Sun-Yat-Sen University,Guangzhou 510060,China);High-dose toremifene plus EP regimen in the treatment of refractory advanced non-small cell lung cancer[J];中国肿瘤临床与康复;2004-06
2 ZHANG Xueyan, LI Qiang,HAN Yiping, LIU Zhongling. Department of Respiratory Medicine, Chang Hai Hospital, Second Military Medical University, Shanghai 200433, China;Synergistic effect of toremifene and cisplatin on human lung cancer cell line A549[J];中华肿瘤杂志;2002-06
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