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《Chinese Journal of Clinical Oncology and Rehabilitation》 2004-06
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Clinical observation of bone metastasis pain treated with sodium ibandronate at different dosages

WANG Huai-zhang, MENG Zhao zhong,JI She-qing (Henan Tumor Hospital,Zhengzhou 450003,China)  
Objective To observe the efficacy of different dosages of sodium ibandronate in treatment of bone metastasis pain.Methods Seventy six patients with malignant bone metastasis were randomly divided into 3 groups A,B and C.Four weeks constituted one treatment course,during which group A was given 2mg,group B 4 mg and group C 6 mg,and a total of 3 treatment courses were given.Evaluation was conducted after 4,8 and 12 weeks.Results Evaluation at 4 weeks found obvious difference between group C and groups A and B( P 0.005, P 0.05),but no obvious difference was seen between groups A and B( P 0.05).Within the first week,the numbers of patients who took less analgesics in groups A,B and C were 1,3 and 6 respectively.Evaluation at 8 weeks found obvious difference between groups B,C and group A( P 0.05, P 0.005),but no difference between group B and group C.Evaluation at 12 weeks found that the effective rates of groups A,B and C were 61.5%,88.0% and 92.0% respectively.Conclusion High dosage of sodium ibandronate has faster,longer and better efficacy than low dosage in treating bone metastasis pain.
【CateGory Index】: R730.5
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