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《Chinese Journal of Clinical Oncology and Rehabilitation》 2012-01
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The effect on gastric cancer of CIK cell mediated by bispecific single-chain antibody in vivo

LIU Hong-yi,LI Rong,LIU Ju-chao,et al(The Surgical Oncology Department of Chinese PLA General Hospital,Beijing 100853,China)  
Objective To investigate the killing effect on gastric cancer cells of CIK cells mediated by bispecific single-chain antibody in vivo.Methods To establish gastric cancer model in nude mice with BGC823 cells.And the mice are divided into 3 groups,which are injected with normal saline,CIK cells and CIK cells+bispecific antibody,respectively,once every 3 days for 6 times.Then remove and weigh the tumors,and calculate the inhibition rate in each group.Results The CIK cells and CIK cells with bispecific single-chain antibody can both inhibit tumor growth in vivo.To compare with the control group,the inhibition rates were 27.4% and 41.7% respectively(P0.05).To compare with CIK cells,CIK cells with bispecific single-chain antibody can inhibit tumor growth(P0.05).Conclusion CIK cells alone can inhibit tumor cell growth,associated with the anti-CEA anti-CD3 bispecific single-chain antibody can significantly enhance antitumor effect.
【Fund】: 国家高技术研究发展计划(2006AA02Z4B9)
【CateGory Index】: R735.2
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