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《Chinese Journal of Clinical Oncology and Rehabilitation》 2012-01
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The effect on gastric cancer of CIK cell mediated by bispecific single-chain antibody in vivo

LIU Hong-yi,LI Rong,LIU Ju-chao,et al(The Surgical Oncology Department of Chinese PLA General Hospital,Beijing 100853,China)  
Objective To investigate the killing effect on gastric cancer cells of CIK cells mediated by bispecific single-chain antibody in vivo.Methods To establish gastric cancer model in nude mice with BGC823 cells.And the mice are divided into 3 groups,which are injected with normal saline,CIK cells and CIK cells+bispecific antibody,respectively,once every 3 days for 6 times.Then remove and weigh the tumors,and calculate the inhibition rate in each group.Results The CIK cells and CIK cells with bispecific single-chain antibody can both inhibit tumor growth in vivo.To compare with the control group,the inhibition rates were 27.4% and 41.7% respectively(P0.05).To compare with CIK cells,CIK cells with bispecific single-chain antibody can inhibit tumor growth(P0.05).Conclusion CIK cells alone can inhibit tumor cell growth,associated with the anti-CEA anti-CD3 bispecific single-chain antibody can significantly enhance antitumor effect.
【Fund】: 国家高技术研究发展计划(2006AA02Z4B9)
【CateGory Index】: R735.2
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【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 ZHOU Qi-Ming1,2, WU Pei-Hong1,2, ZHAO Ming1,2, WANG Qi-Jing1,3, HUANG Li-Xi1,3, LI Yong-Qiang1,3, CHEN Shi-Ping1,3, XIA Jian-Chuan1,31. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China2. Department of Imaging and Interventional Radiology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China 3. Department of Biotherapy, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China;Short-term Curative Efficacy of Cytokine-induced Killer Cells Combined Micro-invasive Treatments on Hepatocellular Carcinoma[J];Chinese Journal of Cancer;2006-11
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4 Shi Ming, Wang Fusheng, Zhang Bing et al. 302 Hospital of PLA, Beijing 100039, China;Evaluation of safety and efficiency of treatment with autologous cytokine-induced killer cell for hepatocellular carcinoma[J];Medical Journal of Chinese People's Liberation Army;2004-04
5 Chen Jianpeng, Luo Rongcheng, Ding Xuemei, et al. Center of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Effects of cytokine-induced kill cell (CIK) and IL-2 on the secretion of thyroxine by thyroid papillary carcinoma[J];Medical Journal of Chinese People's Liberation Army;2007-05
6 LIU Chang,WANG Shi-yong,JIAO Xue,LIU Di-jie,HUANG Wen-yue,MA Ke-ji,WANG Jia-ling(Department of Biotherapy and Laboratory of Biotherapy,Fourth Affiliated Hospital,China Medical University,Shenyang 110032 China);Antitumor effect of antigen-pulsed DC-CIK cells against prostate cancer DU145 cells[J];Progress of Anatomical Sciences;2012-03
7 QIN Fuli 1 ZHANG Shaolin 1 SUN Hui 1 XI Yuren 1( 1Department of Hematology, the First Affiliated Hospital Zhengzhou University, Zhengzhou, 450052, China);Study of the effect of PHA on proliferation and cytotoxicity of CIK cells[J];Journal of Clinical Hematology;2004-06
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9 ZHAO Qun, LI Yong, ZHANG Hui, CHEN Shao-xuan, YANG Jin-qiang, FAN Li-qiao, SONG Zhen-chuan, WANG Li-li, KUANG Gang, JIAO Kun, ZHOU Hong-wei (Department of Surgery, Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang 050011, China);Anti-tumor effects of L-OHP and CIK cells on transplantable peritoneal metastasis of human gastric cancer in nude mice[J];Immunological Journal;2007-02
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