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《Chinese Journal of Clinical Oncology and Rehabilitation》 2012-01
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Clinical course and potential prognostic factors of 146 breast cancer patients with liver metastasis

ZHANG Ling-xiao,WANG Jia-yu,YUAN Peng,et al(Department of Medical Oncology,Cancer Institute & Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100021,China)  
Objective To investigate the clinical course,efficacy of treatment,prognosis and relevant influencing factors of breast cancer patients with liver metastasis.Methods Female breast cancer patients who had liver as their first site of metastases and were treated in Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College during 2005~2010 were taken retrospectively into the study.The clinical,pathological and survival data of them were collected for prognostic analysis.Results The median diseases free survival(DFS),progression free survival(PFS) and post metastasis survival(MSR) of the whole group was 19.1 months,9 months and 22 months respectively.The survival rates decreased yearly,with 69.8% of the first year,43.4% and 31.7% of the following two years.The response rate of the whole group was 59.4%,while the clinical benefit rate was 84.4%,showing a comparative good response towards treatment.Multivariate analysis suggested the subtype of triple negative breast cancer and the short interval of disease free survival were independent predictors of poor survival after liver metastases(P=0.006.P=0.008,respectively).Conclusion Due to the current comprehensive treatment,the survival of breast cancer patients with live metastasis has been evidently improved.However,those with triple negative phenotype or with quick metastasis to liver still experience a poor outcome and therefore call for a more appropriate way of treatment.
【CateGory Index】: R737.9
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