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《Chinese Journal of Clinical Oncology and Rehabilitation》 2012-01
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The comparative analysises between CT-simulator and conventional simulator for patients with breast cancer after modified radical mastectomy

CHENG Guang-hui,SHI Dan,GUO He,et al(Department of Radiotherapy,China-Japan Union Hospital,Jilin University,Changchun 130033,China)  
Objective To compare the dosimetry of CT-simulator and conventional simulator about breast cancer patients after modified radical mastectomy.Method CT-simulator was conducted for 83 breast cancer patients who had received breast modified radical mastectomy,and the conventional treatment was simulated.The dose volume histograms(DVH) were conducted to compare the ratio about V5,V10,V20,V30 of the ipsilateral and bilateral lung and the ratios of target volumes which received the doses for 40 Gy,45 Gy,50 Gy(PTV40,PTV45,PTV50),PTV60,PTV70,the max dose(MAX) in CT-simulator and conventional simulator planning.At the same time,we measured the thickness of the chest wall of the patients,and analyzed the relationships between the thickness of the chest wall and two treatment modes,and followed-up the patients about irradiation pneumonitis.Results The ratios of V5,V10,V20,V30 about ipsilateral and bilateral lung,and PTV40,PTV45,PTV50 for the conventional treatment were less than those for the CT-simulator.The ratios of PTV60,PTV70 and MAX were more than those for the CT-simulator.The average thickness of chest wall was 22.9 mm.There were negative correlations between the thicknesses of the chest wall and the target volume,the doses of normal tissue for the conventional simulator,but no correlations for CT-simulator.The rate of following-up was 90.4%,and the ratio of irradiation pneumonitis was 12.0%(9/75).Conclusion The CT-simulator was better than conventional simulator for the patients who had received breast modified radical mastectomy.Though the lung dose of the conventional simulator was better than that for CT-simulator,but the rate of irradiation pneumonitis for CT simulator was not increased.CT-simulator was better than the conventional simulator in breast modified radical mastectomy patients.
【Fund】: 吉林省科技厅社发处项目资助(20090458);; 吉林省自然科学基金项目(201015183)
【CateGory Index】: R737.9
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