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《Chinese Journal of Clinical Oncology and Rehabilitation》 2012-01
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Study of S-1 combined with cisplatin in patients of advanced gastric cancer

ZHOU Wei-wei,DAI Hong,YAN Dong,et al(Department of Clinical Oncology,Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences,Beijing 100020,China)  
Objective To evaluate the efficacy and toxicity of the regimen of S-1 combined with cisplatin in patients of advanced gastric cancer.Methods Twenty seven patients of advanced gastric cancer were treated with the combination therapy of S-1(doses based on patients′ body surface area: 1.25 m2,40 mg,bid;1.25~1.50 m2,50 mg,bid;1.50 m2,60 mg,bid,on days 1 through 14) plus cisplatin(75 mg/m2 from day 1 through day 2) every 21 days.The evaluation of efficacy and toxicity was performed after every 2 cycles.Results All 27 patients were assessed for efficacy and toxicity.CR was achieved in 1 case(3.7%),PR in 14 cases(51.9%),SD in 7 cases(25.9%),PD in 5 cases(18.5%).The overall response rate was 55.6%(95% confidence interval: 35.5%~74.5%) and the disease control rate was 81.5%(95% confidence interval: 61.9%~93.6%).The common toxicites of the regimen included myelosuppression,pigmentation and gastrointestinal reactions.Conclusions The regimen of S-1 plus cisplatin is effective against advanced gastric cancer with acceptable toxicity.
【CateGory Index】: R735.2
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