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《Chinese Journal of Clinical Oncology and Rehabilitation》 2012-01
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Evaluation of FUDR and 5-Fu in neoadjuvant chemotherapy regimen in breast cancer

YANG Shen-li,YANG Jie,YE Guo-lin,et al(Foshan City First People Hospital,Guangdong 528000,China)  
Objective To compare the efficacy and toxicity of FUDR and 5-Fu in CEF regimens as neoadjuvant chemotherapy for breast cancer.Methods Ninety patients with stageⅡ、Ⅲ breast cancer were randomly divided into two groups,experimental group received FUDR in CEF regimen every 3 weeks,and control group received 5-Fu in CEF regimen every 3 weeks,all groups for 2 or 4 cycles of neoadjuvant chemotherapy.Results In experimental group,2 patients was complete remission(CR),25 patients was partial remission,and total effective rate(RR)was 60.0%.In control group,3 patients was complete remission(CR),22 patients was partial remission,and total effective rate(RR)was55.6%.There was not significant difference between the two groups(P0.05).The side effects,including nausea,vomiting,marrow depression,the experimental group was lower than the control group(P0.05),alopecia and costive were similar in the two groups(P0.05).Conclusions 5-Fu insteaded by FUDR in CEF regimen as neoadjuvant chemotherapy for breast cancer is a good choice.
【CateGory Index】: R737.9
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