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《Chinese Journal of Clinical Oncology and Rehabilitation》 2012-06
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The relativity study of DLL4 and VEGF proteins in breast cancer

CAO Wen-qing,ZHANG Jing,ZHAO Feng-xia,et al(Department of General Surgery,Hebei Provincial People's Hospital,Shijiazhuang 050051,China)  
Objective To investigate the expressions and significance of Delta-like ligand 4(DLL4) and vascular endothelial growth factor(VEGF) proteins in breast cancer tissues.Methods Immunohistochemical method was used to detect the expression of DLL4 and VEGF in 60 cases of breast cancer tissues and 20 cases of adjacent normal breast tissues,and the relationship between DLL4 or VEGF expressions and clinicopathological features of breast cancer was analyzed.Results The expression of DLL4 and VEGF in breast cancer tissues were remarkably higher than those in normal breast tissues(P0.05).The expressions of DLL4 in breast cancer were related with the histological grade,clinical stage,lymph node metastasis and diameter of tumor,the expressions of VEGF were in breast cancer were related with the histological grade,clinical stage and lymph node metastasis(P0.05).The expressions of DLL4 were positively correlated to the expressions of VEGF(r=0.462,P0.001).Conclusions The expressions of DLL4 and VEGF are related to invasion and metastasis of breast cancer,DLL4 and VEGF may have synergetic effects.
【CateGory Index】: R737.9
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