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《Chinese Journal of Clinical Oncology and Rehabilitation》 2012-06
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Clinical observation of advanced colorectal cancer of irinotecan combined with capecitabine after treatment failure of chemotherapy by oxaliplatin

XUE Zhong,CAO Jie,ZHOU Jian(Department of oncology,The Chinese Medicine Hospital of Changzhou,Changzhou 213000,China)  
Objective To observe effect and safety of advanced colorectal cancer of irinotecan combined with capecitabine after treatment failure of chemotherapy by oxaliplatin.Methods The 32 advanced colorectal cancer patients who OXA chemotherapy failed as the research object,CPT-11combined with Xeloda regimen were used,in particular:CPT-11 100mg/m2;Xeloda 2000mg/m2·d-1,2 times daily,altogether 14 days,every three weeks at a time.Observation the curative effect and adverse reaction of patients.Results In 32 cases,2 cases were CR,16cases were PR,RR were 56.25%,the main adverse reactions were Ⅰ-Ⅱ degree bone marrow depression,nausea and vomiting,diarrhea,hand-foot syndrome.Conclusions The curative effect of CPT-11 combined with Xeloda treatment after failure of chemotherapy with oxaliplatin in colorectal cancer is tolerated well and satisfactory.
【CateGory Index】: R735.3
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