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《Chinese Journal of Clinical Oncology and Rehabilitation》 2012-06
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Clinical observation of advanced colorectal cancer of irinotecan combined with capecitabine after treatment failure of chemotherapy by oxaliplatin

XUE Zhong,CAO Jie,ZHOU Jian(Department of oncology,The Chinese Medicine Hospital of Changzhou,Changzhou 213000,China)  
Objective To observe effect and safety of advanced colorectal cancer of irinotecan combined with capecitabine after treatment failure of chemotherapy by oxaliplatin.Methods The 32 advanced colorectal cancer patients who OXA chemotherapy failed as the research object,CPT-11combined with Xeloda regimen were used,in particular:CPT-11 100mg/m2;Xeloda 2000mg/m2·d-1,2 times daily,altogether 14 days,every three weeks at a time.Observation the curative effect and adverse reaction of patients.Results In 32 cases,2 cases were CR,16cases were PR,RR were 56.25%,the main adverse reactions were Ⅰ-Ⅱ degree bone marrow depression,nausea and vomiting,diarrhea,hand-foot syndrome.Conclusions The curative effect of CPT-11 combined with Xeloda treatment after failure of chemotherapy with oxaliplatin in colorectal cancer is tolerated well and satisfactory.
【CateGory Index】: R735.3
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHANG Wen , ZHAO Zi-yi, WU Qing, CHENG Jia, XU Nong, WU Chang-ping, LI Jin, XU Li-gong. Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai 200032 , China;Multicenter phase Ⅱ study of modified FOLFIRI regimen in the advanced colorectal cancer patient refractory to fluoropyrimidine and oxaliplatin[J];Chinese Journal of Oncology;2006-10
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Yu-Hong Li,1,2 Feng-Hua Wang,1,2 Dong-Sheng Zhang,1,2 Zhi-Qiang Wang,1,2 Fen Feng,1,2 Li Zhang,1,2 Rui-Hua Xu,1,2 Wen-Qi Jiang1,2 and You-Jian He1,21.State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P.R.China 2.Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, 510060, P.R.China;Efficacy of FORFIRI regimen on oxaliplatin-based chemotherapy-failed advanced colorectal cancer[J];Chinese Journal of Cancer;2009-09
2 Jiang Bo,Zhao Jinqi,Tu Changling,Liu Kun (Department of Cadre's Clinical Oncology,Yunnan Tumor Hospital,Kunming 650118,China);Observation of Effect of Oxaliplatin Combined with Xeloda Regimen on Patients with Advanced Colon Cancer[J];Journal of Basic and Clinical Oncology;2008-03
3 Wang Cailing,Wang Junsheng(Anyang Tumor Hospital,Anyang 455000,China);The Clinical Observation of Irinotecan Combined with Capecitabine in the Treatment of Advanced Gastric Cancer as Second-Line Chemotherapy Regimen[J];Journal of Basic and Clinical Oncology;2010-01
4 LI Su-yi, LIU Lin, GU Xiao-yi, JIANG Zao, WANG Cai-lian, DONG Li-jun, WAN Jian-ping. Tumor Center of the Affiliated ZhongDa Hospital of Eastsouth University, Nanjing 210009, China;Oxaliplatin combined with 5-flurouracil, leucoverini regimen for patients with advanced colorectal cancer[J];Chinese Clinical Oncology;2006-08
5 LU Xian-mei, ZHU Ying-jie, GU Ying, ZHENG Jian (Longhua Hospital Affiliated to Shanghai University of Chinese Medicine, Shanghai 200032,China);Chinese Reports on the Effect and Safety of FOLFOX or FOLFIRI for Advanced Colorectal Cancer[J];Journal of Liaoning University of Traditional Chinese Medicine;2010-01
6 WANG Xin,WU Wei-xin,LV Xia,SU An,XIAO Li Department of oncology,Xiamen Zhongshan Hospital Xiamen University 361004,China;Effects of systemic and interventional chemotherapy with CPT-11 + xeloda for the liver metastasis from colorectal carcinoma[J];Journal of Modern Oncology;2007-08
7 LI Yujie,CHE Xiangming,LI Haijun,GAN Jianxin,Prakash,LIAO Xinhua,ZHANG Danjie,BI Tieqiang First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China;Comparison between neoadjuvant chemotherapy and operation for colorectal liver metastasis:A Meta-analysis[J];Journal of Modern Oncology;2012-03
8 HE Mei-wen,YU Ding,BAI Zhi-Jun,et al.Gastrointestinal Surgery,Peking University Shenzhen Hospital,Shenzhen Guangdong 518036,China.;Clinical analysis of drug treatment of advanced gastric cancer.[J];Journal of Clinical and Experimental Medicine;2010-13
9 Suyi Li, Lin Liu, Xiaoyi Gu, Zao Jiang, Cailian Wang Tumor Center of the Affiliated Zhongda Hospital of Eastsouth University, Nanjing 210009, China;Oxaliplatin combined with 5-fluorouracil, leucovorin regimen for patients with advanced colorectal cancer[J];中德临床肿瘤学杂志(英文版);2007-03
10 ZHOU Jian-feng, CHEN Shu-chang, BAI Chun-mei, WANG Yu-zhou, ZHAO Lin, NING Xiao-hong (Department of Oncology, Peking Union Hospital,Peking Union Medical College,Chinese Academy of Medical Science,Beijing 100730,China);Multivariate regression analysis on prognostic factors for advanced colorectal carcinoma[J];China Oncology;2007-08
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Irinotecan Cooperative Group of Clinic Research Corresponding author:ZHANG Li,C ancer Center of Sun Yat-sen University, Guangzhou 510060, China;Campto (CPT-11) treatment of advanced large intestinal cancer: clinical ex perience[J];Chinese Journal of Oncology;2003-06
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