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《Chinese Journal of Clinical Oncology and Rehabilitation》 2018-09
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Clinical pathological analysis of 108 young patients with lung cancer

CHANG Xiu-jun;WANG Zi-tong;DUAN Yong;LI Fu-gen;Department of Thoracic Surgery,Beijing Chest Hospital,Capital Medical University;  
Objective To investigate the clinical characteristics in young patients with lung cancer. Methods From January 2012 to May 2017,108 patients ≤40 years with lung cancer were selected at Beijing Chest Hospital and 50 patients at 60 ~ 75 years with lung cancer were selected at the same time. The pathological characteristics were analyzed and compared between the elderly patients and the young patients.Cox regression model was used to analyze factors influencing the prognosis. Results The young patients with lung cancer were characterized by adenocarcinoma,low degree of differentiation,Ⅲ ~ Ⅳ TNM staging and non-smoking history and the elder patients were characterized by squamous cell carcinoma,high degree of differentiation,Ⅰ ~ Ⅱ TNM staging and smoking history( all P 0. 05). Gene mutation did not occurred in most patients in both groups and the percentage of non-gene mutation was higher in elder patients than in young patients. Surgery was the primary treatment strategy for both groups and the incidence of surgery was higher in in elder patients than in young patients. The diagnostic time was the initial diagnosis for most patients in both groups and the initial diagnosis rate was was higher in in elder patients than in young patients. Both groups visited the hospitals with some symptom and the visit rate was higher in young patients with symptom than in elder patients( all P 0. 05). The median survival was 20 months for the young group and 21 months for the eld group and the 5-year survival was 14. 8% for the young group and 14. 0% for the eld group( P 0. 05). Cox regression analysis revealed that smoking history,pathological differentiation,TNM staging and EGFR mutation were independent factors influencing the prognosis( all P 0. 05).Conclusion The young patients with lung cancer were characterized by adenocarcinoma,low degree of differentiation,Ⅲ ~ Ⅳ TNM staging and non-smoking history. Smoking history,pathological differentiation,TNM staging and EGFR mutation were independent factors influencing the prognosis.
【CateGory Index】: R734.2
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