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《Chinese Journal of Clinical Oncology and Rehabilitation》 2018-09
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Significance of ovarian malignancy risk model and copenhagen index in differentiating benign and malignant ovarian tumors

MA Yu-xiang;LIU Guang-lian;XIE Jie;Department of Gynaecology and Obstetrics,Yuyang District Maternal and Child Health Care Hospital;  
Objective To evaluate the values of ovarian malignancy risk model( ROMA) and copenhagen index( CPH-I) in differentiating benign and malignant ovarian tumors. Methods A totsl of 120 patients with ovarian tumors treated at Yuyang District Maternal and Child Health Care Hospital from February 2013 to January 2018 were retrospective studied. Among them,60 patients with ovarian cancer were included in cancerous group,60 patients with benign ovarian tumors were included in tumor group and 60 healthy individuals were involved in the normal group. The serum levels of human epididymal secretory protein( HE4) and carbohydrate antigen 125( CA125) were detected,and the values of ROMA and CPH-I were calculated. Results The levels of HE4 and CA125 were higher in the cancerous group than in the tumor and normal groups( all P 0. 05). There was no significant difference in the level of HE4 and CA125 between tumor group and normal group( P 0. 05). The ROMA and CPH-I were higher in the cancerous group than in the tumor group and normal group( all P 0. 05). The ROMA and CPH-I were higher in the tumor group than in the normal group( all P 0. 05). The sensitivity of HE4,CA125,ROMA and CPH-I in the differential diagnosis of ovarian cancer was 81. 7%,73. 3%,95. 0% and 100. 0% respectively( all P 0. 05),and the specificity was 88. 3%,85. 0%,81. 7% and 85. 8%,respectively( P 0. 05). Conclusion ROMA and CPH-I in the differential diagnosis of benign and malignant ovarian tumors is superior to the traditional tumor markers CA125 and HE and they were objective risk assessment tools and have good clinical application values.
【Fund】: 陕西省卫生厅(2015L04-01-5)
【CateGory Index】: R737.31
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