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《Chinese Journal of Clinical Oncology and Rehabilitation》 2018-09
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Comparision of immunohistochemistry between core needle biopsy and intraoperative resection in patients with breast cancer

CUI Xu;HUA Xi;Department of Pathology,Weinan Central Hospital;Department of Ultrasound,Weinan Central Hospital;  
Objective To compare the results of immunohistochemistry between core needle biopsy and intraoperative resection in patients with breast cancer for hollow needle aspiration biopsy and intraoperative resection specimens of breast cancer patients before and after surgery,and to evaluate the accuracy of core needle biopsy hollow needle aspiration biopsy in the diagnosis of breast cancer. Methods A total of244 patients with breast clinically highly suspicious malignant breast masses treated in at Weinan Central Hospitalour hospital from May 2016 to May 1818 were selected as the study subjects. Core needle biopsy was carried out and the results were compared with the results of immunohistochemistry. Results Of the244 patients who underwent core needle biopsy,68 patients( 27. 9%) were diagnosed with benign tumors and 176 patients( 72. 1%) were diagnosed with malignant tumors. Among the patients undergoing resection for breast cancer,45 patients( 25. 3%) were diagnosed by core needle biopsyto have benign tumors and133 patients( 74. 7%) were diagnosed to have malignant tumors. The diagnostic accuracy of core needle biopsy was 94. 9%( 169/178). The sensitivity of core needle biopsy for the malignant tumors was 95. 5%( 127/133) and the specificity was 93. 3%( 42/45). According to the consistency test,the Kappa value of this experiment was 0. 8952,indicating that the consistency of the immunohistochemical findings of the core needle biopsy in the diagnosis of breast cancer and intraoperative resection specimens is high,and can be used in place of the surgical pathology results for breast cancer. Conclusion Core needle biopsy has high accuracy,sensitivity and specificity. It can be used for clinical diagnosis and differential diagnosis of breast cancer. It is worthy of clinical promotion.
【CateGory Index】: R737.9
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