Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical Oncology and Rehabilitation》 2018-09
Add to Favorite Get Latest Update

Efficacy of small dose olanzapine in the treatment of nausea and vomiting caused by adjuvant concurrent chemoradiotherapy after radical gastrectomy for gastric cancer

SUN Yong-hong;HE Qun-yu;BIE Jun;YANG Mi;QIN Juan;Department of Oncology,The Second Clinical Medical School Affiliated to North Sichuan Medical College/Nanchong Central Hospital;  
Objective To investigate the efficacy of small dose olanzapine in the treatment of nausea and vomiting caused by adjuvant concurrent chemoradiotherapy after radical gastrectomy for gastric cancer. Methods From July 2015 to February 2017,48 patients who underwent surgery for gastric cancer at Nanchong Central Hospital were selected. These patients were randomly divided into a treatment group and a control group with 24 patients in each group. Both group recieved cisplatin concurrent chemoradiotherapy,and before chemotherapy both group received tropisetron plus dexamethasone. The treatment group received oral olanzapine starting from the day of chemotherapy. The incidence and severity of nausea and vomiting were evaluated during the whole process of chemoradiotherapy. Results The proportion of no nausea and vomiting in the treatment group was significantly higher than that in the control group,and the proportion of degree Ⅰ to Ⅲ was significantly less than that of the control group( all P 0. 05). Conclusion Adding olanzapine to tropisetron and dexamethasone significantly improved both acute and delayed nausea and vomiting reaction on cisplatin-based concurrent chemoradiotherapy after radical gastrectomy for gastric cancer,and is worthy of clinic application.
【Fund】: 四川省科技支撑计划(2014SZ0020)
【CateGory Index】: R735.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved