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Effect of calcium, magnesium, zinc, copper and vitamin D supplementation on prevention and treatment of osteoporosis in women over 40 years old

MA Beilei, CAI Meiqin, GAO Peijun, et al. Department of Nutrition, Medical College, Shanghai Jiaotong University,Shanghai 200025, China  
Objective To observe the effect of Calcium, magnesium, zinc, copper and vitamin D supplementation on bone density, osteocalcin and bone symptoms in women over 40 years old. Methods 154 women were selected in Shanghai ,which were divided into intervention group and control group randomly. Premenopausal women were defined as A, postmenopausal women were defined as B. Intervention group A: 38 premenopausal women. Control group A: 40 premenopausal women. Intervention group B: 39 postmenopausal women. Control group B: 37 postmenopausal women. All intervention groups were treated with two Caltrate tablets(each tablet contains calcium 273.5 mg, vitamin D 1.62 μg, magnesium 99.7mg, zinc 3.08 mg, copper 0.51 mg) daily for a period of one year. The BMD of lumbar vertebrae and serum osteocalcin were measured before and after the study, a 24-hour dietary recall was applied to them and the change of bone symptoms were wrote down. Results (1) There is no significant difference in lumbar BMD before and after 6 months' intervention among intervention group. After 1 year's intervention, the lumbar BMD significantly increased (+1.18%) in premenopausal intervention group and significantly decreased(-3.74%) in premenopausal control group. But the lumbar BMD does not have significant difference in postmenopausal intervention and control group before and after intervention. (2)After 6 months and 1 year's intervention, serum BGP decreased significantly in all of the four groups(P0.05). However, the level of serum BGP in both A and B of intervention group is noticeably higher than the control(P0.05).(3)The supplementations significantly relieved local joint pain and the low back pain of the intervention group. Conclusions Calcium, Magnesium, Zinc, Copper and vitamin D Supplementation ameliorates the bone symptoms in women, increases the BMD of premenopausal women and the serum BGP of postmenopausal women whose BMD didn't change significantly. It is suggested that women over 40 years old should be supplemented with nutrients which can benefit bone health in early lifetime to prevent the loss of bone.
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