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Li Yourun~*( , Zhu Man Chen Bingzhen (Department of Chemical Engineering, Tsinghua University, Beijing, 100084)  
A combined approach of thermodynamic analysis and mixed-integer linear programming is presented for performing structural and parameter optimization in the integration of energy system of chemical processes. Tnermodynamic analysis is used to set up a superstructure configuration of energy system in order to reduce the space of search. The application of the combined approach is illustrated by a revamping integration of a large existing energy system in a refinery complex.
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