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《化工学报(英文版)》 1992-01
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A NEW PROCESS FOR THE EXTRACTION OF PENICILLIN G FROM THE FILTRATE OF FERMENTATION BROTH WITH TBP IN BUTYL ACETATE

Yang Zhifa~(**)( ), Yu Shuqiu Chen Jiayong (Institute of Chemical Metallurgy, Academia Sinica, Beijing, 100080) Liu Shouxin~* Zhou Chongwei (North China Pharmaceutical Corporation, Shijiazhuang, 050015, Hebei)  
The mixture of neutral phosphorus esters and butyl acetate (BA) can be used, as the extractant for the extraction of penicillin G. The extraction equilibrium pH can be increased to pH3—4 due to the stronger extraction capability of the solvent mixture, instead of pH1.8—2.2 with butyl acetate as solvent. The experimental results indicate that the total recovery of penicillin G can reach 96.6% with the new extraction process, which is 5—6% higher than that obtained with the traditional process using BA as solvent at pH1.8—2.2.
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