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《中国化学工程学报(英文版)》 2006-01
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Synthesis of Vitamin A Esters by Immobilized Candida sp. Lipase in Organic Media

YIN Chunhua a, b, LIU Tao a and TAN Tianwei a,** a College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China b School of Applied Science, University of Science and Technology Beijing, Beijing 100083, China  
Vitamin A ester was synthesized in organic solvents with immobilized lipase from Candida sp. The types of lipases, influences of solvent, the molar ratio of substrates, the reaction temperature and the water activity in the reaction were studied in detail in order to obtain the optimum conditions for Vitamin A palmitate synthesis. In a system of hexane, 100mg immobilized Candida sp. lipase was used in the presence of 1.2mmol vitamin A acetate and 3.6mmol palmitic acid. The yield of vitamin A palmitate reached 81% in 12h at 25℃. The immobilized Candida sp. lipase was prepared by adsorbing Candida sp. fermentation broth on pretreated textile and could be reused for at least six batches.
【Fund】: Supported by the National Natural Science Foundation of China (No.20325622) Key Technology R&D Programme (No.2001BA708B03-08) and 863 Hi-Technology Research and Development Program of China (No. 2002AA514030).
【CateGory Index】: O621.25
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【Co-citations】
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1 YIN Chun-hua,GAO Ming,LIU Jiang-fan(Department of Biological Science and Technology,School of Applied Science,University of Science and Technology Beijing,Beijing 100083,China);Study of enzymatic synthesis of isopropyl myristate with immobilized lipase[J];China Surfactant Detergent & Cosmetics;2009-06
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