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《中国化学工程学报(英文版)》 2008-05
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Preparation of Ultra-fine Salbutamol Sulfate Particles by Reactive Precipitation and Characterization of Dry Powder Inhalant

XU Jing 1 ,LIU Xiaolin 2,and CHEN Jianfeng 2 1Ningxia University,Yinchuan 750021,China 2 Research Center of the Ministry of Education for High Gravity Engineering and Technology,Beijing University of Chemical Technology,Beijing 100029,China  
The preparation of ultra-fine particles of salbutamol sulphate(SS)was accomplished with a reactive precipitation pathway,in which salbutamol and sulphuric acid were used as reactants with the solvents of ethanol. The effects of sulphuric acid concentration,reaction temperature,stirring rate,and reaction time on the size of the particle were investigated.A binary mixture composed of lactose and SS was prepared to evaluate SS.The results showed that ultra-fine SS particles with controlled diameters ranging between 3μm and 0.8μm and with a narrow distribution could be achieved.The morphology consisting of clubbed particles was successfully obtained.The pu- rity of the particles reached above 98%with UV detection.The dose of dry powder inhalation was obtained by blending the particles with recrystallized lactose,which acted as a carrier.The deposition quantity of the drug in breathing tract was estimated using a twin impinger apparatus.Compared with the Shapuer powder(purchased in the market),the results showed that SS particles had more quantities subsided in simulative lung.
【Fund】: the National High Technology Research and Development Program of China(2001AA218061);; the NationalNatural Science Foundation of China(20236020).
【CateGory Index】: TQ463
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【Co-citations】
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1 ZHU Wan-cheng, CHEN Jian-feng , WANG Yu-hong (Chemical Engineering Department, Qufu Normal University, Qufu 273165, China; Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China);Experimental study on the synthesis of ultra-fine calcium carbonate whiskers in rotating packed bed reactor[J];Material Science and Technology;2005-01
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