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STUDYON EPIDERMALGROWTH FACTOR LEVELSOFSALIVA,GASTRIC JUICE AND SEBUM IN PATIENTSWITH PEPTICULCER DISEASE

chen Shou-po,Lu Guo-jun,wen Shu-hao.Divison of Gastroenterology,Department ofMedicine,Peking Union Medical College Hospital, Beijing  
pidermal growth factor(EGF)has a cytoprotective effect on the upper gastrointestinalmucosa. The purpose of the present study was designed to evaluate whether patients withgastric ulcer(GU)or duodenal ulcer(DU) have a deficiency of EGF release compared tonormal subjects and patients with mild chronic superficial gastritis(CSG).Blood and salivawere taken at fasting condition.The basal and pentagastrin-stimulated(6μ g/kg,im)gastricjuice were collected.The levels of EGF were measured by radioimmunoassay.The resultsshowed that:(1)The levels of EGF in saliva,gastric juice and serum were significantly lowerin GU and DU patients than those in normal controls and patients with CSG.(2) Nodifference of EGF concentration in saliva,gastric juice or serum between GU and DUpatients.(3)After the stimulation of pentagastrin,no significant increase of gastric EGFcontent was observed.We conclude that the deficiency of EGF release may be involved in thepathogenesis of peptic ulcer disease.
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