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EVALUATION OF THE EFFICACY OF LOSEC IN RELIEVING ESOPHAGEAL CHEST PAIN

Luo Jin-yan,Wang Jin-hai,Gong Jun,et al.Digestive Function Laboratory,Second Clinical College,xian Medical University  
total of 78 patients with esophageal chest pain were treated with Losec(20 mg oncedaily),including GER(18),GERD(n=24),achalasia(5),iffuse esophageal spasm(DES,n=5),hypertensive lower esophageal sphincter(HLES,n=6),presbyesophagus (n=5),esophagealcarcinoma(n=9) and others(n=8). 40 patients with hyperdyskinesia of esophageal motilitywere divided at random to either Losec 20mg once daily plus Nifedipinum l0mg thrice dailyor Nifedipinum l0mg thrice daily.The results showed that Losec was efficacious for relievingthe chest pain caused by esophageal diseases, the total pain relieving rate being 8.1%.Among them,the pain relieving rates were 88.9%in GER, 87.5%in GERD, 66.1% inachalasia,80% in DES,50% in HLES,80% in presbyesopagus and 88.9% in esophagealcarcinoma.The pain relieving rates were 74.1% in Losec plus Nifedipinum and 36.8% inNifedipinum alone(P0.05).
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