CHANGES OF INTRACELLULAR VITAMINS LEVELS IN GASTRICMUCOSA OF PATIENTS WITH GASTRIC CANCER
Zhu Shun-shi,Li Rong-rong,Shi Yao,et al.Shanghai Institute of Disease Shanghai Hospital
n order to study further the relationship between gastric cancer and vitamins,assays forestimation of cellular vitamins were designed,and 27 resected stomach specimens(20 cancersand 7 non-cancer lesions)were subject to such determination. The tissues from the cancer orbenign lesions,the para-cancer or para-lesion mucosae and normal mucosae were taken out,the mucosal cells of the above three parts were isolated,and the cellular concentration ofvitamin A、E、C、B12,folic acid and β-carotene were determined. The results showed that thecellular levels of vitamin A、E、B12,and β-carotene in the cancer and para-cancer mucosaewere significantly lower than those in the corresponding benign lesion and para-lesionmucosae(P0.01),but no statistical difference between the cancerous and the paracancermucosa cells.This paper confirmed an interrelationship existing in between gastric cancergrowth and vitamins,and that,this kind of correlation might have been present already inthe precancerous cells. It may be then possible to intervene the process of gastriccancinogensis by correcting the abnormal vitamin metabolism in the precancerous stage.