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STUDY ON THE THERAPEUTIC EFFECTS OF TETRAMETHYLPYRAZINE ON ACUTE HEAMORRHAGICNECROTIZING PANCREATITIS IN RATS AND ITS MECHANISMS

Wang Xing-peng,Xu Jia-yu,Yuan Yao-zong,et al.Rui-jin Hospital,Shanghai Second Medical Universty  
The purpose of the present study is to evaluate the therapeutic effects of Tetra-methylprazine(TMP),a chinese medcine,on acute hemorrhagic necrotizing pancreatitis(AHNP)in rats,and it’s possible mechanisms.All rats were divided into 3 groups:shamoperation,AHNP untreated,and AHNP TMP treated.AHNP models were made in rat byligation of duodenal loop with injection of 5%sodium taurocholate.Biochemical profiles usedwere plasma TXB2,6-keto-PGF1α,lipidperoxide(LPO) and elastase inhibitory capacity (EIC).Results of the study indicated that ratio of TXB2/6-keto-PGF1α,and LPO value were muchelevated, EIC decreased after induction of AHNP,as compared with sham operative rat.Treatment with TMP could lower the elevated TXB2/6-keto-PGF1αand LPO,and increaseEIC, significantly(P 0.05).Pathologic examination of pancreas by light and electronmicroscopy was much pronounced,and survival times were much prolonged in the TMPtreated groups than its in untreated groups.In conclusion,TMP has therapeutic effects onAHNP in rats,and it might be due to maintaining the balance between TXA2 and PGI2,scavenge oxygen free radical and depressing elastase activity.
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