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《Chinese Journal of Geriatric Dentistry》 2018-01
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The applications and prospects of doxorubicin-photodynamic combination therapy in malignant tumors

WANG Huan-huan;FU Zhi-guang;WEN Ning;Department of stomatology, Chinese PLA General Hospital;  
Malignant tumors are serious diseases threatening human health and life worldwide with high fatality rate.Surgery, chemotherapy, radiotherapy and combined therapies are still the first-line treatments for malignant tumors. However,there are some limitations and side effects in these conventional treatments. Photodynamic therapy(PDT), as a new anti-tumor method, has become an effective strategy for superficial tumors, depending on its high specificity, minimal invasion,low systemic toxicity and repeatability. Recent years, chemotherapy combined with photodynamic therapy has been applied to the treatment of malignant tumors gradually and has obtained better effects. Photodynamic therapy can help chemotherapy target specifically and boost the deposition of nanoparticle drugs in tumors by enhanced vascular permeability. Meanwhile,chemotherapy can enhance the efficacy of PDT by targeting surviving cancer cells or by inhibiting regrowth of damaged tumor blood vessels. The combination of phototherapy and chemotherapy(chemophototherapy, CPT) can improve the anti-tumor effects and decrease the systemic toxic and side effects. Taking doxorubicin as a representative of chemotherapeutic agents, this article summarizes the applications of doxorubicin-photodynamic combined therapy in malignant tumors and looks forward to its development prospects.
【Fund】: 国家高技术研究发展计划(项目编号:2013AA032201)
【CateGory Index】: R730.5
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