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Effect of maximal medical therapy on refractory unstable angina pectoris

Gao Kai;Wang Shiwen;LiuGuoshu et al.(General Hospital of PLA,Beijing 100853)  
Objective To study the effect of maximal medical therapy on refractory unstable angina pectoris.Methods A group of 88 aged and pre-aged patients with unstable angina pectoris were analyzed retrospectively.The patients were classified as medically refractory group or as medically stabilized group.Results Eighty-one patients with persistent unstable angina got relief after maximal medical therapy with 4 to 5 classes of medication;only 7 patients(8.0%) ultimately proved to be refractory to maximal medical therapy.Patients with refractory unstable angina were more likely to have electrocardiographic changes on anterior chest leads and ST-segment depression was present in 6(85.7%) of the patients.Patients receiving intravenous heparin(6patients,85.7%) and β-blockers (6 patients,85.7%) were also more frequently seen in patients with refractory unstable angina than in patients who stabilized on medical therapy.The rate of in-hospital myocardial infarction(2 patients,28.6%),death 1 patient,14.3%) and the number of patients with PTCA therapy(3 patients,42.9%) in the group of refractory unstable angina were significantly higher in the refractory group than in patients who stabilized on medical therapy.Conclusions These results suggest that maximal medical therapy is of help in reduceing the rate of refractory unstable angina pectoris.
【CateGory Index】: R541.405
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