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The effect of vitamin E on blastogenic response of splenocytes aud lipefuscin conteut in the heart and brain of aged mice

Ma Xuanyue;Liu Yajuan;Feng Biao, et al.(Department of Nutrition,Norman Bethune Medical University, Changchun 130021)  
Objective In this study, the effect of vitamin E (Vit E) on cell-mediated immune functions and lipid peroxidation in the brain and heart of aged mice were observed. Methods Semi-purified diet containing 30×10(-6) or 500×10(-6) DL-α-tocopherol (Vit E) was fed for 8 weeks to young (3 months) and old ( 18 months) Swiss mice. The average daily intake of Vit E was 42mg/kg or 2.5mg/kg body weight for the young and 30mg/kg or 1.8mg/kg body weight for the aged. The blastogenic response of splenocytes as well as the serum Vit E and lipofuscin levels in brain and heart were measured. Results It is shown that the old mice fed with 500×10(-6) Vit E diet had a significantly higher serum Vit E level and blastogenic response of splenocytes to Con A and LPS than those fed with 30× 10(-6) Vit E diet (P0.01). However, lipofuscin level in the brain and heart of the aged mice declined substantially by Vit E supplementation (heart:P0.01, brain:P 0.05 ).Conclusions Higher dose of dietary Vit E supplementation significantly enhanced the serum Vit E level and blastogenic response of splenocytes of aged mice,while obviously inhibited lipid peroxidation and thereby reduced lipofuscin accumulation in the tissues.
【CateGory Index】: R977.25
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