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《Chinese Journal of Epidemiology》 2005-09
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A study on the sero-epidemiology of hepatitis B in Chinese population aged over 3-years old

LIANG Xiao-feng, CHEN Yuan-sheng , WANG Xiao-jun , HE Xiong , CHEN Li-juan , WANG Jun , LIN Chang-ying, BAI Hu-qun , YAN Jun, CUI Gang , YU Jing-jin . Chinese Center for Disease Control and Prevention, Beijing 100050,China  
Objective To better understand and measure the impact from immunization activities over the last 10-years, we conducted a sero-epidemiological study using the remaining blood samples of a nationwide survey on Nutrition and Health in Chinese residents, in 2002. Methods HBsAg, anti-HBs and anti-HBc in blood samples were tested using enzyme-linked immunosorbent assay(ELISA) reagents and revised by solid phase radioimmunoassay and Abbott ELISA reagents. Results Among population older than 3 years, the prevalence rates of HBsAg, anti-HBs and hepatitis B virus(HBV) infection were 9.09% , 37.48% and 50.04% but for children between 3 and 12 year olds, they were 5.03%, 45.33% and 29.10% respectively. Among population older than 3 years, the rates of HBsAg and HBV infection in urban area were4.61% and 43.51% , but the rates in rural area were 9.41% and 56.77% respectively while for children from 3-years to 12-years old, they rates were 2.10%, 20.45% in urban area and 8.25%, 39.22% in rural areas, respectively. Conclusion Results revealed that since the hepatitis B vaccine was introduced into the expanded program on immunization(EPI) from 1992, the prevalence rates of HBsAg and HBV infection, especially in the children from 3 to 12 years of age, had obviously declined, suggesting that some changes had happened in the epidemic characters of hepatitis B in China.
【Key Words】: Hepatitis B Sero-epidemiology Hepatitis B vaccine Vaccinate
【CateGory Index】: R181.3;
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